Results 81 to 90 of about 815,112 (296)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Data-driven optimization of Antarctic shallow ice core site selection

Journal of Glaciology
Antarctic ice cores provide highly detailed climate histories; yet, the existing proxy record is limited by uneven spatial and temporal coverage. Collecting new ice cores will improve our understanding of climate processes in Antarctica, but the cost of ...
Advik Eswaran, Olivia J. Truax, Shelley MacDonell, Kenichi Matsuoka, Peter D. Neff, Eric J. Steig, V. Holly L. Winton, T. J. Fudge   +7 more
doaj   +1 more source

Direct north-south synchronization of abrupt climate change record in ice cores using Beryllium 10 [PDF]

Climate of the Past, 2007
A new, decadally resolved record of the ¹⁰Be peak at 41 kyr from the EPICA Dome C ice core (Antarctica) is used to match it with the same peak in the GRIP ice core (Greenland).
G. M. Raisbeck, F. Yiou, J. Jouzel, T. F. Stocker   +3 more
doaj  

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Chronology for climate change: Developing age models for the biogeochemical ocean flux study cores [PDF]

, 1995
We construct age models for a suite of cores from the northeast Atlantic Ocean by means of accelerator mass spectrometer dating of a key core, BOFS 5K, and correlation with the rest of the suite.
Manighetti, B, McCave, IN, Shackleton, NJ, Maslin, M   +3 more
core  

(Table 1.2.3.1) Abundance of sympagic meiofauna in the bottom-ice section of Polarstern cruise ANT-XXIII/7 sea-ice cores

, 2010
samples are taken from the lowermost 5 cm of sea-ice cores (diameter 9 cm), the depth ice/snow is the maximum ice depth (=ice thickness) measured from ice ...
Klaus M Meiners (6979676), Nicolaus, Marcel, Maike Kramer (7921526), Swadling, Kerrie M, Kiko, Rainer, Rainer Kiko (6978311), Kramer, Maike, Werner, Iris, Iris Werner (6982319), Meiners, Klaus M, Annette Scheltz (7921532), Kerrie M Swadling (7921529), Scheltz, Annette, Marcel Nicolaus (6887372)   +13 more
core   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Methane concentration in ice cores: A tool to reveal firn-ice properties and past climate changes [PDF]

, 2006
Polar ice sheets provide an archive of ancient air trapped in small air bubbles that can be analyzed directly for its composition. Deep ice core drillings in Antarctica and Greenland penetrated more than 3’000 m in the ice and provided mostly undisturbed
Spahni, Renato
core