Results 71 to 80 of about 702,524 (252)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Simulating the temperature and precipitation signal in an Alpine ice core [PDF]
Climate of the Past, 2013 Accumulation and δ18O data from Alpine ice cores provide information on past temperature and precipitation. However, their correlation with seasonal or annual mean temperature and precipitation at nearby sites is often low.
S. Brönnimann +4 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Response of a marine-terminating Greenland outlet glacier to abrupt cooling 8200 and 9300 years ago [PDF]
, 2011 Long-term records of Greenland outlet-glacier change extending beyond the satellite era can inform future predictions of Greenland Ice Sheet behavior. Of particular relevance is elucidating the Greenland Ice Sheet's response to decadal- and centennial ...
Greg S. Babonis +13 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Long-term record of H2O2 in polar ice cores [PDF]
, 1986 At Dye 3 and Camp Century, Greenland, and at Byrd Station, West-Antarctica, ice cores were drilled to bedrock. They offer an archive of solid precipitation over the last 50.000 to 100,OOO years.
Neftel, A., Jacob, P., Klockow, D.
core +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Assessing the continuity of the blue ice climate record at Patriot Hills, Horseshoe Valley, West Antarctica [PDF]
, 2016 We use high resolution Ground Penetrating Radar (GPR) to assess the continuity of the Blue Ice Area (BIA) horizontal climate record at Patriot Hills, Horseshoe Valley, West Antarctica.
Turney, Chris S. M. +42 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source