Results 61 to 70 of about 815,112 (296)

Towards radiocarbon dating of ice cores [PDF]

, 2009
Instruments and MethodsInternational audienceA recently developed dating method for glacier ice, based on the analysis of radiocarbon in carbonaceous aerosol particles, is thoroughly investigated.
Kellerhals, T., Boutron, Claude,, Jenk, T. M., Sigl, Michael, Schwikowski, Margit, Synal, H.-A., Jenk, Theo M., Synal, Hans-Arno, Boutron, Claude, F., Wacker, Lukas, Boutron, Claude, Gabrieli, Jacopo, Barbante, C., Gabrieli, J., Gäggeler, H. W., Sigl, M., Jenk, Theo Manuel, Szidat, S., Schwikowski, M., Gäggeler, Heinz W., Wacker, L., Szidat, Sönke, Barbante, Carlo, Wacker, Luckas, Kellerhals, Thomas, Kellerhals, T. (author), Sigl, M. (author), Szidat, S. (author), Gäggeler, H.W. (author), Barbante, C. (author), Jenk, T.M. (author), Boutron, C. (author), Synal, H.-A. (author), Gabrieli, J. (author), Wacker, L. (author), Schwikowski, M. (author)   +35 more
core   +2 more sources

IODP Drilling of the “Shackleton Sites” on the Iberian Margin: A Plio-Pleistocene Marine Reference Section of Millennial-Scale Climate Change [PDF]

Scientific Drilling, 2010
Few marine sediment cores have played such a pivotal role in paleoclimate research as those recovered from the Portuguese Margin, including MD95-2039 to MD95-2042 (hereafter referred to as the “Shackleton sites”) (Fig. 1).
Henrique Duarte, Luis Batista, Gabriella Carrara, Fatima Abrantes, David Hodell   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Test-Bed Performance of an Ice-Coring Drill Used with a Hot Water Drilling System

Journal of Marine Science and Engineering, 2019
Ice cores from ice shelves contain abundant paleoclimatic information and provide essential information concerned with the prediction of future climatic change and global sea level variations.
An Liu, Rusheng Wang, Xiaopeng Fan, Yang Yang, Xingchen Li, Liang Wang, Pavel Talalay   +6 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Summer temperature trend over the past two millennia using air content in Himalayan ice [PDF]

Climate of the Past, 2007
Two Himalayan ice cores display a factor-two decreasing trend of air content over the past two millennia, in contrast to the relatively stable values in Greenland and Antarctica ice cores over the same period.
S. Hou, S. Hou, S. Hou, J. Chappellaz, J. Jouzel, P. C. Chu, V. Masson-Delmotte, D. Qin, D. Raynaud, P. A. Mayewski, V. Y. Lipenkov, S. Kang   +11 more
doaj  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Agile Sub-Ice Geological (ASIG) Drill development and Pirrit Hills field project

Annals of Glaciology, 2021
A new drilling system was developed by the US Ice Drilling Program (IDP) to rapidly drill through overlying ice to collect subglacial rock cores. The Agile Sub-Ice Geological (ASIG) Drill system is capable of drilling up to 700 m of ice in a continuous ...
Tanner Kuhl, Chris Gibson, Jay Johnson, Grant Boeckmann, Elliot Moravec, Kristina Slawny   +5 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source