Results 111 to 120 of about 4,479,560 (350)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Emergent magnetic monopole dynamics in macroscopically degenerate artificial spin ice

Science Advances, 2019
We present direct, real-time observations of emergent magnetic monopole dynamics in highly frustrated artificial spin ice. Magnetic monopoles, proposed as elementary particles that act as isolated magnetic south and north poles, have long attracted ...
Alan Farhan, M. Saccone, Charlotte F. Petersen, S. Dhuey, R. Chopdekar, Yen-Lin Huang, N. Kent, Zuhuang Chen, M. Alava, T. Lippert, A. Scholl, S. van Dijken   +11 more
semanticscholar   +1 more source

Evolution of the structure of amorphous ice - from low-density amorphous (LDA) through high-density amorphous (HDA) to very high-density amorphous (VHDA) ice

, 2005
We report results of molecular dynamics simulations of amorphous ice for pressures up to 22.5 kbar. The high-density amorphous ice (HDA) as prepared by pressure-induced amorphization of Ih ice at T=80 K is annealed to T=170 K at various pressures to ...
D. Donadio, Lindahl E., M. Parrinello, R. Martoňák   +3 more
core   +1 more source

Photodissociation of water in crystalline ice: a molecular dynamics study [PDF]

, 2005
Ultraviolet irradiation of ice is of great interest for understanding the chemistry in both atmospheric and astrophysical environments. In interstellar space, photodissociation of H2O molecules can be a driving force behind the chemistry on icy dust ...
Al-Halabi, Allen, Aschi, Bartels, Bernal, Bursulaya, Chakarov, Chan, Chipman, Dobbyn, Ehrenfreund, Ewine F. van Dishoeck, Geert-Jan Kroes, Gerakines, Ghormley, Huber, Jorgensen, Khusnatdinov, Klein, Klán, Kobayashi, Langford, Larsen, Leto, Miller, Osted, Poulsen, Sander, Schinke, Stefan Andersson, Thomsen, van Harrevelt, van Harrevelt, Watanabe, Yabushita, Yang, Zhang   +36 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Retrieval of Cloud Macro‐Physical Properties Using theFY‐4A Advanced Geostationary Radiation Imager (AGRI) and the Geostationary Interferometric Infrared Sounder (GIIRS)

Geophysical Research Letters
This study presents a novel approach for conducting all‐day retrieval of cloud macro‐physical properties (single‐layer cloud phase, cloud top height, and cloud base height for optical thickness less than 10) using the Advanced Geostationary Radiation ...
Bin Guo, Feng Zhang, Zhijun Zhao, Jinyu Guo, Wenwen Li   +4 more
doaj   +1 more source

Treatment of the ice-shelf backpressure and buttressing in two horizontal dimensions

Journal of Glaciology
The ice discharge from the grounded parts of marine ice sheets into the ocean is modulated by their floating extensions – ice shelves. The ice-shelf impact on the grounded ice is typically described as ‘backpressure’ or ‘buttressing’.
Olga Sergienko
doaj   +1 more source

Coupled atmosphere-ice-ocean dynamics in Dansgaard-Oeschger events

Quaternary Science Reviews, 2019
The Dansgaard-Oeschger events of the last ice age are among the best studied abrupt climate changes, yet a comprehensive explanation is still lacking.
Camille Li, A. Born
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source