Results 91 to 100 of about 804,547 (290)

Bio-Processes of the Oxidation Ditch When Subjected to a Sub-Arctic Climate [PDF]

, 1972
Alaska's far northern area is sparsely populated primarily because of a severe climate which varies from northern temperate to Arctic. Construction and power costs are high. Skilled operating personnel are scarce and expensive, if available. Receiving
Murphy, R. Sage, Ranganathan, K. R.
core  

Design hazard identification and the link to site experience [PDF]

, 2017
The training, development and routes to charteredship of building design engineers have undergone a major transformation in recent years. Additionally, the duration and quality of site experience being gained by designers is reducing.
ASCE (American Society of Civil Engineers), Billy Hare, Bimal Kumar, Blockley D, Crossrail, Gelernter M, Graham Hayne, Hayne G, HMG, HMG (Her Majesty’s Government), HSE (Health and Safety Executive), ICE (Institution of Civil Engineers), IStructE (Institution of Structural Engineers), Scheer DR   +13 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Optimization of CO2 production rate for firefighting robot applications using response surface methodology [PDF]

, 2018
A carbon dioxide gas-powered pneumatic actuation has been proposed as a suitable power source for an autonomous firefighting robot (CAFFR), which is designed to operate in an indoor fire environment in our earlier study.
Ajala, MT, Khan, MR, Mohamad Nor, MI, Oladokun, MO, Salami, MJE, Shafie, AA   +5 more
core   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Усилия горячей штамповки биметаллических поршней [PDF]

, 2010
Наведено результати теоретичного дослідження процесу гарячого штампування заготівок біметалевих поршнів ДВС. Отримано інженерні формули, що дозволяють визначити енергосилові параметри деформування.The results of theoretical research of the bimetallic ICE
Ковшанова, Т. Н., Лобанов, В. К., Пашкова, Г. И.   +2 more
core  

Block freeze-concentration of coffee extract: Effect of freezing and thawing stages on solute recovery and bioactive compounds [PDF]

, 2014
Coffee extract was freeze-concentrated using the total block technique. The effects of four parameters were evaluated: the initial coffee mass fraction (5 and 15% w/w), the cooling temperature ( 10 and 20 C), the heating temperature (20 and 40 C ...
Hernández Yáñez, Eduard, Moreno, F.L., Raventós Santamaria, Mercè, Ruiz, Y.   +3 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source