Results 61 to 70 of about 544,035 (290)

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Strengthening ice through cyclic loading

Journal of Glaciology, 2017
New experiments reveal that the flexural strength of fresh water, columnar-grained ice loaded normal to the columns may be increased by about a factor of two upon reversed cyclic loading at a frequency of ~0.1 Hz at stress amplitudes of 1.3–2.6 MPa.
DANIEL ILIESCU, ANDRII MURDZA, ERLAND M. SCHULSON, CARL E. RENSHAW   +3 more
doaj   +1 more source

Effect of Lateral and Stress‐Dependent Viscosity Variations on GIA Induced Uplift Rates in the Amundsen Sea Embayment

Geochemistry, Geophysics, Geosystems, 2021
Accurate glacial isostatic adjustment (GIA) models are required for correcting measurements of mass change in Antarctica and for improving knowledge of the sub‐surface, especially in areas of large current ice loss such as the Amundsen Sea Embayment (ASE)
B. Blank, V. Barletta, H. Hu, F. Pappa, W. van der Wal   +4 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Ice Concentration Scaling Laws for Freshwater Lakes in Numerical Weather and Climate Prediction

Geophysical Research Letters, 2023
If lake ice is assumed to deform and fail as a linear viscoelastic material under the action of wind stress, then a simple ice concentration scaling law can be constructed suitable for one‐dimensional lake models embedded within environmental prediction ...
Murray D. MacKay
doaj   +1 more source

Making EBSD on water ice routine [PDF]

, 2015
Electron backscatter diffraction (EBSD) on ice is a decade old. We have built upon previous work to select and develop methods of sample preparation and analysis that give >90% success rate in obtaining high-quality EBSD maps, for the whole surface area (
Daghlian, C., Seidemann, M., Becroft, L., Lilly, K., NWO-NSO: The role of grain size in the rheology of planetary ice, Durham, W. B., Golding, N., Piazolo, S., Caswell, T., Prior, D. J., Structural geology and EM, Diebold, S., Vaughan, M., Easingwood, R., Baker, I., Goldsby, D., Obbard, R., Wilson, C. J L   +17 more
core   +2 more sources

On the effect of rheology on seasonal sea-ice simulations [PDF]

Annals of Glaciology, 1991
A generalized numerical model which allows for a variety of non-linear rheologies is developed for the seasonal simulation of sea-ice circulation and thickness. The model is used to investigate the effects (such as the role of shear stress and the existence of a flow rule) of different rheologies on the ice-drift pattern and build-up in the Arctic ...
Chi F. Ip, William D. Hibler, Gregory M. Flato   +2 more
openaire   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source

Tidal bending of ice shelves as a mechanism for large-scale temporal variations in ice flow [PDF]

The Cryosphere, 2018
GPS measurements reveal strong modulation of horizontal ice shelf and ice stream flow at a variety of tidal frequencies, most notably a fortnightly (Msf) frequency not present in the vertical tides themselves.
S. H. R. Rosier, G. H. Gudmundsson
doaj   +1 more source