Results 121 to 130 of about 226,235 (355)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Microfluidic‐Driven Lipid Nanoparticles for Improved miRNA Delivery via Endo‐Lysosomal Trafficking Optimization

Advanced Science, EarlyView.
This study investigates the impact of various post‐processing methods (filtration, sonication, dialysis, and heating) on lipid nanoparticles produced using microfluidics. The nanoparticles are designed for efficient delivery of miRNA into cells. The work highlights how processing conditions influence nanoparticle stability and quality, providing ...
Alicja Kosik‐Kozioł, Michał Pruchniewski, Daniel Rybak, Piotr Jenczyk, Karolina Zakrzewska, Magdalena Bartolewska, Sławomir Błoński, Paweł Nakielski, Filippo Pierini   +8 more
wiley   +1 more source

Feedbacks between ice and ocean dynamics at the West Antarctic Filchner-Ronne Ice Shelf in future global warming scenarios [PDF]

, 2016
The ice flow at the margins of the West Antarctic Ice Sheet is moderated by large ice shelves. Their buttressing effect substantially controls the mass balance of the WAIS and thus its contribution to sea level rise.
Goeller, Sebastian, Timmermann, Ralph
core  

The sedimentary legacy of a palaeo-ice stream on the shelf of the southern Bellingshausen Sea: Clues to West Antarctic glacial history during the Late Quaternary [PDF]

, 2010
A major trough ("Belgica Trough") eroded by a palaeo-ice stream crosses the continental shelf of the southern Bellingshausen Sea (West Antarctica) and is associated with a trough mouth fan ("Belgica TMF") on the adjacent continental slope.
Benetti, S., Dowdeswell, J.A., Ehrmann, W., Graham, Alastair G.C., Grobe, H., Hillenbrand, Claus-Dieter, Larter, Robert D., Ó Cofaigh, C.   +7 more
core   +1 more source

Cross‐Platform Biosensing of Immune Receptors Using Peptide‐Functionalized Graphene

Advanced Science, EarlyView.
A peptide‐functionalized graphene biosensor enables sensitive and selective detection of living immune cells. Targeting Formyl‐Peptide Receptor 2 (FPR2), the assay is demonstrated on model cells and primary human neutrophils. The same assay is applied to two complementary platforms: graphene‐enhanced surface plasmon resonance for optical benchmarking ...
Ahmar Hasnain, Heiko Heilmann, Annabel Pohl, Celine Weber, Bernd Bufe, Alexey Tarasov   +5 more
wiley   +1 more source

A mathematical model of melt lake development on an ice shelf [PDF]

, 2018
The accumulation of surface meltwater on ice shelves can lead to the formation of melt lakes. Melt lakes have been implicated in ice shelf collapse; Antarctica's Larsen B Ice Shelf was observed to have a large amount of surface melt lakes present ...
Alexiades V., Arthern R., Banwell A., Crank J., D. Flocco, D. L. Feltham, IPCC, Moaveni S., Paterson W., S. C. Buzzard, Scambos T., Silva T. A. M., Taylor P.   +12 more
core   +4 more sources

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Bidirectionally Thermochromic Nanocolloid System for on‐Demand Optical Switching and Agricultural Energy Management

Advanced Science, EarlyView.
A bidirectionally thermochromic nanocolloid system is developed for facility agriculture. The bidirectional and wide‐temperature response dynamically modulates light radiation, stabilizing the indoor climate, improving supplemental lighting efficiency, and accelerating plant photosynthesis.
Qinbo Jiang, Jiayi Li, Hui Zhang
wiley   +1 more source

Seasonal and diurnal variability of sub-ice platelet layer thickness in McMurdo Sound from electromagnetic induction sounding [PDF]

The Cryosphere
Here, we present observations of temporal variability of sub-ice platelet layer over seasonal and diurnal timescales under Ice Shelf Water-influenced fast ice in McMurdo Sound.
G. M. Brett, G. H. Leonard, W. Rack, C. Haas, C. Haas, C. Haas, C. Haas, P. J. Langhorne, N. J. Robinson, A. Irvin, A. Irvin   +10 more
doaj   +1 more source

Bathymetry beneath the Amery ice shelf, East Antarctica, revealed by airborne gravity

, 2021
Junjun
openalex   +1 more source