Results 111 to 120 of about 478,422 (316)

Effective Rheology Across the Fragmentation Transition for Sea Ice and Ice Shelves

Geophysical Research Letters, 2019
Sea ice and ice shelves can be described by a viscoelastic rheology that is approximately linear elastic and brittle at high strain rates and viscously shear thinning at low strain rates.
J. Åström, D. Benn
semanticscholar   +1 more source

Phenotyping Healthcare Use 2–3 Decades Before the First Multiple Sclerosis Demyelinating Event

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Phenotype hospital, physician, and emergency department (ED) visits by diagnoses and specialty up to 29 years pre‐multiple sclerosis (MS) onset versus a matched population without MS. Methods We identified people with MS (PwMS) using population‐based administrative data from Ontario, Canada (1991–2020).
Helen Tremlett, Karl Everett, Colleen J. Maxwell, Feng Zhu, Ayesha Asaf, Ping Li, Kyla A. McKay, Yinshan Zhao, Ruth Ann Marrie   +8 more
wiley   +1 more source

Relevance of Kappa and Lambda Free Light Chains in Autoimmune Astrocytopathy Associated With Anti‐GFAP Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction The kappa‐free light chain (κ‐FLC) index is known to be highly sensitive and specific for diagnosing multiple sclerosis (MS), while little is understood about lambda (λ)‐FLC. This study assessed the κ‐FLC and λ‐FLC indices in autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy.
Michael Levraut, Romain Marignier, Mikael Cohen, Jeanne Benoit, Cassandre Landes‐Chateau, Elisabeth Maillart, Marion Cremoni, Barbara Seitz‐Polski, Anne‐Laurie Pinto, Pauline Dumez, Jérôme Honnorat, Christine Lebrun‐Frenay   +11 more
wiley   +1 more source

The Creep of Ice Shelves: Interpretation of Observed Behaviour [PDF]

Journal of Glaciology, 1973
AbstractAvailable measurements of creep rates and dimensions of ice shelves are used, in conjunction with equations derived in a companion paper (Thomas, 1973), to evaluate the flow law parameters B and n for stresses down to 104 N m−2. The results show good agreement with laboratory work at higher stresses.
openaire   +3 more sources

Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β

Advanced Biology, EarlyView.
This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer, Markus Michael Kramer, Miguel Baños, Merlin Moritz Grimm, Manfred Fliegauf, Bodo Grimbacher, Gerald Radziwill, Sven Rahmann, Wilfried Weber   +8 more
wiley   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

The Amundsen Sea and the Antarctic Ice Sheet [PDF]

Oceanography, 2012
A few decades ago, Antarctic ice sheets were expected to grow as the atmosphere warmed and increasing poleward moisture transport added snowfall to regions that would remain below freezing year-round.
Stan Jacobs, Adrian Jenkins, Hartmut Hellmer, Claudia Giulivi, Frank Nitsche, Bruce Huber, Raul Guerrero   +6 more
doaj  

Changes in flow of Crosson and Dotson ice shelves, West Antarctica, in response to elevated melt

, 2018
. Crosson and Dotson ice shelves are two of the most rapidly changing outlets in West Antarctica, displaying both significant thinning and grounding-line retreat in recent decades.
D. Lilien, I. Joughin, Ben E. Smith, D. Shean   +3 more
semanticscholar   +1 more source

Surface and basal boundary conditions at the Southern McMurdo and Ross Ice Shelves, Antarctica

Journal of Glaciology, 2019
We derive the surface and basal radar reflectance and backscatter coefficients of the southern McMurdo Ice Shelf (SMIS) and part of the nearby Ross Ice Shelf (RIS), Antarctica, from radar statistical reconnaissance using a 60-MHZ airborne survey.
C. Grima, I. Koch, J. Greenbaum, K. Soderlund, D. Blankenship, D. Young, Dustin M. Schroeder, Sean J. Fitzsimons   +7 more
semanticscholar   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source