Results 71 to 80 of about 478,422 (316)

Instantaneous Antarctic ice sheet mass loss driven by thinning ice shelves

Geophysical Research Letters, 2019
Recent observations show that the rate at which the Antarctic ice sheet (AIS) is contributing to sea level rise is increasing. Increases in ice‐ocean heat exchange have the potential to induce substantial mass loss through the melting of its ice shelves.
G. Gudmundsson, F. Paolo, S. Adusumilli, H. Fricker   +3 more
semanticscholar   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Overview of areal changes of the ice shelves on the Antarctic Peninsula over the past 50 years [PDF]

The Cryosphere, 2010
In recent decades, seven out of twelve ice shelves around the Antarctic Peninsula (AP) have either retreated significantly or have been almost entirely lost. At least some of these retreats have been shown to be unusual within the context of the Holocene
A. J. Cook, D. G. Vaughan
doaj  

Modelling the influence of marine ice on the dynamics of an idealised ice shelf

Journal of Glaciology, 2023
Understanding the dynamic behaviour of ice shelves, specifically the controls on their ability to buttress the flow of ice into the ocean, is critical for predicting future ice-sheet contributions to sea level rise.
Lisa Craw, Felicity S. McCormack, Sue Cook, Jason Roberts, Adam Treverrow   +4 more
doaj   +1 more source

Functional role and folding properties of the glucan‐binding domain of oral bacterial glucansucrase

FEBS Letters, EarlyView.
The role of the glucan‐binding domain in Streptococcus sobrinus glucansucrase was examined, focusing on its impact on enzymatic activity, dextran binding, and structural stability of deletion mutants and a circularly permuted protein. Our research revealed that glucosyl transfer efficiency is linked to cooperative interdomain folding.
Hideyuki Komatsu, Takayuki Sadakane, Yudai Murata, Junichi Taira, Hiroshi Sakamoto, Takao Kodama   +5 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Antarctic ice sheet response to sudden and sustained ice-shelf collapse (ABUMIP)

Journal of Glaciology, 2020
Antarctica's ice shelves modulate the grounded ice flow, and weakening of ice shelves due to climate forcing will decrease their ‘buttressing’ effect, causing a response in the grounded ice.
Sainan Sun, Frank Pattyn, Erika G. Simon, Torsten Albrecht, Stephen Cornford, Reinhard Calov, Christophe Dumas, Fabien Gillet-Chaulet, Heiko Goelzer, Nicholas R. Golledge, Ralf Greve, Matthew J. Hoffman, Angelika Humbert, Elise Kazmierczak, Thomas Kleiner, Gunter R. Leguy, William H. Lipscomb, Daniel Martin, Mathieu Morlighem, Sophie Nowicki, David Pollard, Stephen Price, Aurélien Quiquet, Hélène Seroussi, Tanja Schlemm, Johannes Sutter, Roderik S. W. van de Wal, Ricarda Winkelmann, Tong Zhang   +28 more
doaj   +1 more source

Quantifying Antarctic‐Wide Ice‐Shelf Surface Melt Volume Using Microwave and Firn Model Data: 1980 to 2021

Geophysical Research Letters, 2023
Antarctic ice‐shelf stability is threatened by surface melt, which has been implicated in several ice‐shelf collapse events over recent decades. Here, we first analyze cumulative days of wet snow/ice status (“melt days”) for melt seasons from 1980 to ...
Alison F. Banwell, Nander Wever, Devon Dunmire, Ghislain Picard   +3 more
doaj   +1 more source