Results 41 to 50 of about 1,845,174 (287)

The Fate of Frozen Carbonated Water at Europa-like Conditions

The Planetary Science Journal
We present the results of experiments probing the retention of CO _2 in crystalline water ice, frozen sodium chloride (NaCl) brines, and flash-frozen carbonated water using diffuse reflectance infrared spectroscopy. Characteristic absorptions alluding to
Swaroop Chandra, William T. P. Denman, Michael E. Brown   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CO2 Infrared Spectra on Silicate Dust Grain Analogs: Implications for JWST Observations

The Astrophysical Journal Letters
Carbon dioxide is one of the three most abundant species within the ice mantles around dust grains inside molecular clouds. Since a substantial number of interstellar grains are made of siliceous materials, we have studied the infrared profile of CO _2 ...
Tushar Suhasaria, Vanessa Leuschner, Cornelia Jäger, Caroline Gieser, Thomas Henning   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cover ICE 2019

, 2019
These proceedings are a collection of papers presented in English at The Second PGSD UST International Conference on Education (ICE) held in Universitas Sarjanawiyata Tamansiswa on October 5, 2019.
ICE 2019, ICE 2019
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An 8×8 pixel array IC for X-ray spectroscopy [PDF]

2000 IEEE Nuclear Science Symposium. Conference Record (Cat. No.00CH37149), 2002
An integrated circuit providing 64 channels of low-noise signal processing electronics in an 8x8 pixel arrangement has been developed as part of an integrated silicon detector array for high count-rate x-ray spectroscopy applications. Each pixel features low-noise charge integration, programmable peaking time and gain, and an output driver.
Krieger, Bradley, Ewell, Kathryn, Ludewigt, Bernhard A., Maier, Michael R., Markovic, Dejan, Milgrome, Oren, Wang, Y. June   +6 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Model-scale tests on the ice-structure interaction process in shallow water

, 2022
A series of model-scale experiments on the ice loading process against a wide, inclined structure in shallow water was conducted in the Aalto Ice Tank. Experiments with three different ice strengths were performed. Based on the results of the experiments,
Lemström, Ida, Tuhkuri, Jukka, Polojärvi, Arttu, Puolakka, Otto   +3 more
core   +1 more source

Vacuum-UV spectroscopy of interstellar ice analogs [PDF]

Astronomy & Astrophysics, 2014
Dust grains in cold circumstellar regions and dark-cloud interiors at 10-20 K are covered by ice mantles. A nonthermal desorption mechanism is invoked to explain the presence of gas-phase molecules in these environments, such as the photodesorption induced by irradiation of ice due to secondary ultraviolet photons.
Cruz-Diaz, G. A., Caro, G. M. Muñoz, Chen, Y. -J., Yih, T. -S.   +3 more
openaire   +4 more sources