Results 51 to 60 of about 1,845,174 (287)
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
BiomimeticsA nature-inspired approach was employed through the development of dopamine-modified epoxy coating for anti-icing applications. The strong affinity of dopamine’s catechol groups for hydrogen bonding with water molecules at the ice/coating interface was ...
Mohammad Sadegh Koochaki +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Single particle ICP-TOFMS on previously characterised EGRIP ice core samples: new approaches, limitations, and challenges [PDF]
The CryospherePolar ice contains chemical impurities, which can be used as a proxy for the past climate, using state-of-the-art chemical methods. Despite its capability to access critical physicochemical parameters of insoluble particles, such as number concentration,
N. Stoll +9 more
doaj +1 more source
The State of CO and CO2 Ices in the Kuiper Belt as Seen by JWST
The Planetary Science Journal, 2023 JWST has shown that CO _2 and CO are common on the surfaces of objects in the Kuiper Belt and have apparent surface coverages even higher than that of water ice, though water ice is expected to be significantly more abundant in the bulk composition ...
Michael E. Brown, Wesley C. Fraser
doaj +1 more source
Broadband spectroscopy of astrophysical ice analogues
Astronomy & Astrophysics, 2019 Context.Reliable, directly measured optical properties of astrophysical ice analogues in the infrared and terahertz (THz) range are missing from the literature. These parameters are of great importance to model the dust continuum radiative transfer in dense and cold regions, where thick ice mantles are present, and are necessary for the interpretation ...
Giuliano, B. M. +11 more
openaire +4 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
NMR characterizations of the ice binding surface of an antifreeze protein. [PDF]
PLoS ONE, 2010 Antifreeze protein (AFP) has a unique function of reducing solution freezing temperature to protect organisms from ice damage. However, its functional mechanism is not well understood.
Jiang Hong +5 more
doaj +1 more source
Disorder Analysis in Infrared Spectroscopy of Acetylene Ice
The Journal of Physical Chemistry AA new method to investigate disorder in ice films is proposed and applied to acetylene ice. It is based on a quantitative analysis of the infrared spectrum data, which includes: the Brendel-Bormann model for the material's dielectric function; molecular vibration modes calculated by density functional theory (DFT); a monomer-dimer model for amorphous ...
S. L. A. Mello +5 more
openaire +2 more sources