Results 51 to 60 of about 95,067 (301)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Fate of Frozen Carbonated Water at Europa-like Conditions

The Planetary Science Journal
We present the results of experiments probing the retention of CO _2 in crystalline water ice, frozen sodium chloride (NaCl) brines, and flash-frozen carbonated water using diffuse reflectance infrared spectroscopy. Characteristic absorptions alluding to
Swaroop Chandra, William T. P. Denman, Michael E. Brown   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Direct observation of proton transfer in ice Ih using femtosecond spectroscopy

, 2010
We studied proton transfer in ice samples containing the photoacid 8-hydroxypyrene-1,3,6-trisulfonic acid and the base sodium formate using femtosecond pump−probe spectroscopy.
Cox, M.J., Bakker, H.J., Timmer, R.L.A.
core   +1 more source

CO2 Infrared Spectra on Silicate Dust Grain Analogs: Implications for JWST Observations

The Astrophysical Journal Letters
Carbon dioxide is one of the three most abundant species within the ice mantles around dust grains inside molecular clouds. Since a substantial number of interstellar grains are made of siliceous materials, we have studied the infrared profile of CO _2 ...
Tushar Suhasaria, Vanessa Leuschner, Cornelia Jäger, Caroline Gieser, Thomas Henning   +4 more
doaj   +1 more source

The new frontier of microstructural impurity research in polar ice

Annals of Glaciology, 2023
Deciphering the localisation of solid and dissolved impurities on the micron-scale in glacial ice remains a challenge, but is critical to understand the integrity of ice core records and internal deformation.
Nicolas Stoll, Pascal Bohleber, Remi Dallmayr, Frank Wilhelms, Carlo Barbante, Ilka Weikusat   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Multiproxy investigation of the last 2,000 years BP marine paleoenvironmental record along the western Spitsbergen margin

Arctic, Antarctic, and Alpine Research, 2022
A reconstruction of the last 2,000 years BP of environmental and oceanographic changes on the western margin of Spitsbergen was performed using a multidisciplinary approach including the fossil assemblages of diatoms, planktic and benthic foraminifera ...
Fiorenza Torricella, Viviana Maria Gamboa Sojo, Karen Gariboldi, Nessim Douss, Maria Elena Musco, Chiara Caricchi, Renata Giulia Lucchi, Katia Carbonara, Caterina Morigi   +8 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mid-IR and VUV spectroscopic characterisation of thermally processed and electron irradiated CO2 astrophysical ice analogues [PDF]

, 2022
The astrochemistry of CO2 ice analogues has been a topic of intensive investigation due to the prevalence of CO2 throughout the interstellar medium and the Solar System, as well as the possibility of it acting as a carbon feedstock for the synthesis of ...
Das, A, Mifsud, Duncan V., McCullough, R.W., Herczku, P., Ioppolo, S., Chou, S-L, Rajasekhar, B.N., Rajasekhar, BN, Juhász, Z., Paripás, B., Kanuchova, Z, Mifsud, DV, Rahul, KK, Ioppolo, S, Bhardwaj, A, Lo, J.-I., Field, T.A., Das, A., McCullough, RW, Kovacs, STS, Rahul, K.K., Mason, NJ, Chou, S.-L., Hailey, Perry A., Lo, J-I, Mason, N.J., Sulik, B., Cheng, B.-M., Field, TA, Paripas, B, Pavithraa, S., Muina, AT, Pavithraa, S, Juhasz, Z, Bhardwaj, A., Herczku, P, Kaňuchová, Z., Sivaraman, B., Hailey, PA, Sulik, B, Kovács, S.T.S., Cheng, B-M, Sivaraman, B, Traspas Muiña, A.   +43 more
core   +1 more source