Results 71 to 80 of about 260,252 (303)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Enhancing Icephobic Coatings: Exploring the Potential of Dopamine-Modified Epoxy Resin Inspired by Mussel Catechol Groups

Biomimetics
A nature-inspired approach was employed through the development of dopamine-modified epoxy coating for anti-icing applications. The strong affinity of dopamine’s catechol groups for hydrogen bonding with water molecules at the ice/coating interface was ...
Mohammad Sadegh Koochaki, Gelareh Momen, Serge Lavoie, Reza Jafari   +3 more
doaj   +1 more source

Characterization of individual ice residual particles by the single droplet freezing method: a case study in the Asian dust outflow region [PDF]

Atmospheric Chemistry and Physics, 2018
In order to better characterize ice nucleating (IN) aerosol particles in the atmosphere, we investigated the chemical composition, mixing state, and morphology of atmospheric aerosols that nucleate ice under conditions relevant for mixed-phase clouds.
A. Iwata, A. Matsuki
doaj   +1 more source

Broadband spectroscopy of astrophysical ice analogues

Astronomy & Astrophysics, 2019
Context.Reliable, directly measured optical properties of astrophysical ice analogues in the infrared and terahertz (THz) range are missing from the literature. These parameters are of great importance to model the dust continuum radiative transfer in dense and cold regions, where thick ice mantles are present, and are necessary for the interpretation ...
Giuliano, B. M., Gavdush, A. A., Müller, B., Zaytsev, K. I., Grassi, T., Ivlev, A. V., PALUMBO, Maria Elisabetta, Baratta, G., SCIRE` SCAPPUZZO, Carlotta, Komandin, G. A., Yurchenko, S. O., Caselli, P.   +11 more
openaire   +4 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Two-dimensional infrared spectroscopy of neat ice I_h

Physical Chemistry Chemical Physics, 2016
The assignment of the distinct peaks observed in the OH stretch lineshape of ice Ih is controversial. In contrast to a resent experimental interpretation we find that excitonic cross peaks exist between the dominant exciton states. Opposed to common cases the transition dipole directions between these coupled states are uncorrelated.
Shi, Liang, Skinner, J. L., Jansen, Thomas L. C.   +2 more
openaire   +4 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Impurity Analysis and Microstructure Along the Climatic Transition From MIS 6 Into 5e in the EDML Ice Core Using Cryo-Raman Microscopy

Frontiers in Earth Science, 2019
Impurities in polar ice cores have been studied so far mainly for the purpose of reconstructions of past atmospheric aerosol concentrations. However, impurities also critically influence physical properties of the ice matrix itself.
Jan Eichler, Jan Eichler, Christian Weikusat, Anna Wegner, Birthe Twarloh, Melanie Behrens, Hubertus Fischer, Maria Hörhold, Daniela Jansen, Sepp Kipfstuhl, Urs Ruth, Frank Wilhelms, Frank Wilhelms, Ilka Weikusat, Ilka Weikusat   +14 more
doaj   +1 more source