Results 71 to 80 of about 95,067 (301)

An 8×8 pixel array IC for X-ray spectroscopy [PDF]

2000 IEEE Nuclear Science Symposium. Conference Record (Cat. No.00CH37149), 2002
An integrated circuit providing 64 channels of low-noise signal processing electronics in an 8x8 pixel arrangement has been developed as part of an integrated silicon detector array for high count-rate x-ray spectroscopy applications. Each pixel features low-noise charge integration, programmable peaking time and gain, and an output driver.
Krieger, Bradley, Ewell, Kathryn, Ludewigt, Bernhard A., Maier, Michael R., Markovic, Dejan, Milgrome, Oren, Wang, Y. June   +6 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Cryospheric ecosystems: a synthesis of snowpack and glacial research [PDF]

, 2015
The fourteen letters that contributed to this focus issue on cryospheric ecosytems provide an excellent basis for considering the state of the science following a marked increase in research attention since the new millennium.
Laybourn-Parry, J., Brock, B., B, Brock,, Johanna Laybourn-Parry, Laybourn-Parry, Jo, Tranter, Martyn, Ben Brock, Andy Hodson, Laybourn-Parry, Johanna, Hodson, AJ, Pearce, David, Hodson, A., David Pearce, Pearce, D., Martyn Tranter, Brock, Benjamin, Hodson, Andy, Tranter, M.   +17 more
core   +1 more source

Characterization of individual ice residual particles by the single droplet freezing method: a case study in the Asian dust outflow region [PDF]

Atmospheric Chemistry and Physics, 2018
In order to better characterize ice nucleating (IN) aerosol particles in the atmosphere, we investigated the chemical composition, mixing state, and morphology of atmospheric aerosols that nucleate ice under conditions relevant for mixed-phase clouds.
A. Iwata, A. Matsuki
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Microbiology and atmospheric processes: Biological, physical and chemical characterization of aerosol particles [PDF]

, 2008
The interest in bioaerosols has traditionally been linked to health hazards for humans, animals and plants. However, several components of bioaerosols exhibit physical properties of great significance for cloud processes, such as ice nucleation and cloud
R. Psenner, Ahern, H. E., Psenner, R., P. A. Ariya, Despres, V., Pósfai, Mihály, Moffett, B. F., M. Pósfai, Hill, T. C. J., T. C. J. Hill, Frohlich-Nowoisky, J., B. F. Moffett, Georgakopoulos, D. G., J. Fröhlich-Nowoisky, D. G. Georgakopoulos, Ariya, P. A., V. Després, Pósfai, M., H. E. Ahern   +18 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Optical Constants of Ices Important to Planetary Science from Laboratory Reflectance Spectroscopy

The Planetary Science Journal
Laboratory-derived optical constants are essential for identifying ices and measuring their relative abundances on solar system objects. Almost all optical constants of ices important to planetary science come from experiments with transmission ...
S. C. Tegler, W. M. Grundy, M. J. Loeffler, P. D. Tribbett, J. Hanley, A. V. Jasko, H. Dawson, A. N. Morgan, K. J. Koga, A. O. Madden-Watson, M. D. Gomez, J. K. Steckloff, G. E. Lindberg, S. P. Tan, S. M. Raposa, A. E. Engle, C. L. Thieberger, D. E. Trilling   +17 more
doaj   +1 more source