Results 61 to 70 of about 95,067 (301)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The State of CO and CO2 Ices in the Kuiper Belt as Seen by JWST
The Planetary Science Journal, 2023 JWST has shown that CO _2 and CO are common on the surfaces of objects in the Kuiper Belt and have apparent surface coverages even higher than that of water ice, though water ice is expected to be significantly more abundant in the bulk composition ...
Michael E. Brown, Wesley C. Fraser
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
BiomimeticsA nature-inspired approach was employed through the development of dopamine-modified epoxy coating for anti-icing applications. The strong affinity of dopamine’s catechol groups for hydrogen bonding with water molecules at the ice/coating interface was ...
Mohammad Sadegh Koochaki +3 more
doaj +1 more source
Single particle ICP-TOFMS on previously characterised EGRIP ice core samples: new approaches, limitations, and challenges [PDF]
The CryospherePolar ice contains chemical impurities, which can be used as a proxy for the past climate, using state-of-the-art chemical methods. Despite its capability to access critical physicochemical parameters of insoluble particles, such as number concentration,
N. Stoll +9 more
doaj +1 more source
NMR characterizations of the ice binding surface of an antifreeze protein. [PDF]
PLoS ONE, 2010 Antifreeze protein (AFP) has a unique function of reducing solution freezing temperature to protect organisms from ice damage. However, its functional mechanism is not well understood.
Jiang Hong +5 more
doaj +1 more source
Broadband spectroscopy of astrophysical ice analogues
Astronomy & Astrophysics, 2019 Context.Reliable, directly measured optical properties of astrophysical ice analogues in the infrared and terahertz (THz) range are missing from the literature. These parameters are of great importance to model the dust continuum radiative transfer in dense and cold regions, where thick ice mantles are present, and are necessary for the interpretation ...
Giuliano, B. M. +11 more
openaire +4 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Understanding the polarization signal of spherical particles for microwave limb radiances
, 2006 This paper presents a simple conceptual model to explain that even spherical scatterers lead to a polarization difference signal for microwave limb radiances.
S.A. Buehler +10 more
core +1 more source
Distinguishing ice β-XV from deep glassy ice VI: Raman spectroscopy
Physical Chemistry Chemical Physics, 2019 Evidence for the existence of D2O-ice β-XV is given by the observation of its librational Raman band at 380 cm−1.
Alexander V. Thoeny +2 more
openaire +3 more sources