Results 61 to 70 of about 260,252 (303)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CO2 Infrared Spectra on Silicate Dust Grain Analogs: Implications for JWST Observations

The Astrophysical Journal Letters
Carbon dioxide is one of the three most abundant species within the ice mantles around dust grains inside molecular clouds. Since a substantial number of interstellar grains are made of siliceous materials, we have studied the infrared profile of CO _2 ...
Tushar Suhasaria, Vanessa Leuschner, Cornelia Jäger, Caroline Gieser, Thomas Henning   +4 more
doaj   +1 more source

Energy-filtered transmission electron microscopy of biological samples on highly transparent carbon nanomembranes

, 2011
Ultrathin carbon nanomembranes (CNM) comprising crosslinked biphenyl precursors have been tested as support films for energy-filtered transmission electron microscopy (EFTEM) of biological specimens.
Beyer, André, Büenfeld, Matthias, Gölzhäuser, Armin, Hampp, Norbert, Kühlbrandt, Werner, Rhinow, Daniel, Turchanin, Andrey, Weber, Nils-Eike   +7 more
core   +1 more source

Infrared spectroscopy of solid CO-CO2 mixtures and layers [PDF]

, 2005
The spectra of pure, mixed and layered CO and CO2 ices have been studied systematically under laboratory conditions using infrared spectroscopy. This work provides improved resolution spectra (0.5 cm-1) of the CO2 bending and asymmetric stretching mode ...
Boogert, Boogert, Boonman, Collings, Collings, E. F. van Dishoeck, Ehrenfreund, Ehrenfreund, Ehrenfreund, Elsila, F. A. van Broekhuizen, Falck, Fraser, Gerakines, Gerakines, Gibb, H. J. Fraser, I. M. N. Groot, Nummelin, Pontoppidan, Pontoppidan, Roser, S. Schlemmer, Sandford, Sandford, van Dishoeck, Watanabe, Watson, Whittet   +28 more
core   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Single particle ICP-TOFMS on previously characterised EGRIP ice core samples: new approaches, limitations, and challenges [PDF]

The Cryosphere
Polar ice contains chemical impurities, which can be used as a proxy for the past climate, using state-of-the-art chemical methods. Despite its capability to access critical physicochemical parameters of insoluble particles, such as number concentration,
N. Stoll, N. Stoll, D. Clases, R. Gonzalez de Vega, M. Elinkmann, P. Larkman, P. Larkman, P. Bohleber, P. Bohleber, P. Bohleber   +9 more
doaj   +1 more source

NMR characterizations of the ice binding surface of an antifreeze protein. [PDF]

PLoS ONE, 2010
Antifreeze protein (AFP) has a unique function of reducing solution freezing temperature to protect organisms from ice damage. However, its functional mechanism is not well understood.
Jiang Hong, Yunfei Hu, Congmin Li, Zongchao Jia, Bin Xia, Changwen Jin   +5 more
doaj   +1 more source

Rotationally resolved spectroscopy of (20000) Varuna in the near-infrared [PDF]

, 2014
Models of the escape and retention of volatiles by minor icy objects exclude any presence of volatile ices on the surface of TNOs smaller than ~1000km in diameter at the typical temperature in this region of the solar system, whereas the same models show
Emery, J. P., Licandro, J., Lorenzi, V., Ore, C. M. Dalle, Pinilla-Alonso, N.   +4 more
core   +2 more sources

Neutron spectroscopy of high-density amorphous ice [PDF]

Physica B: Condensed Matter, 1999
Abstract Vibrational spectra of high-density amorphous ice (hda-ice) for H 2 O and D 2 O samples were measured by inelastic neutron scattering. The measured spectra of hda-ice are closer to those for high-pressure phase ice-VI, but not for low-density ice-Ih.
A.I Kolesnikov, J.C Li, N.C Ahmad, C.-K Loong, J Nipko, D Yocum, S.F Parker   +6 more
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source