Results 81 to 90 of about 2,271,419 (323)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A sea-ice thickness retrieval model for 1.4 GHz radiometry and application to airborne measurements over low salinity sea-ice [PDF]

The Cryosphere, 2010
In preparation for the European Space Agency's (ESA) Soil Moisture and Ocean Salinity (SMOS) mission, we investigated the potential of L-band (1.4 GHz) radiometry to measure sea-ice thickness.
L. Kaleschke, N. Maaß, C. Haas, S. Hendricks, G. Heygster, R. T. Tonboe   +5 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Emergence of the Shackleton Range from beneath the Antarctic Ice Sheet due to glacial erosion [PDF]

, 2014
This paper explores the long-term evolution of a subglacial fjord landscape in the Shackleton Range, Antarctica. We propose that prolonged ice-sheet erosion across a passive continental margin caused troughs to deepen and lower the surrounding ice-sheet ...
Fogwill, C. J., Hein, A. S., Kerr, A. R., Kubik, P. W., Stuart, F. M., Sugden, David   +5 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Grounding of an Ice Shelf in the Central Arctic Ocean: A Modeling Experiment [PDF]

, 2003
A numerical ice sheet model was used in a first test towards evaluating the hypothesis that, during a period of large-scale glaciation, an ice shelf emanating from the Barents/Kara Seas grounded across parts of the Lomonosov Ridge to a depth of around ...
Jakobsson, Martin, Paton, Mark, Siegert, M   +2 more
core   +1 more source

Wave attenuation and dispersion due to floating ice covers

, 2019
Experiments investigating the attenuation and dispersion of surface waves in a variety of ice covers are performed using a refrigerated wave flume.
Babanin, A. V., Law, A. W. -K., Parra, S. M., Sree, D. K. K., Wang, D., Yiew, L. J.   +5 more
core   +1 more source

Joint inversion estimate of regional glacial isostatic adjustment in Antarctica considering a lateral varying Earth structure (ESA STSE Project REGINA) [PDF]

, 2017
A major uncertainty in determining the mass balance of the Antarctic ice sheet from measurements of satellite gravimetry, and to a lesser extent satellite altimetry, is the poorly known correction for the ongoing deformation of the solid Earth caused by
Bamber, Jonathan L., Clarke, Peter J., Drinkwater, Mark R., Horvath, Alexander, Horwath, Martin, Klemann, Volker, Konrad, Hannes, Martín-Español, Alba, Pail, Roland, Petrie, Elizabeth J., Sasgen, Ingo, Wouters, Bert   +11 more
core   +3 more sources

Effect of Foot Orthoses on Midfoot Pain and the Volume of Bone Marrow Lesions in the Midfoot: A Randomized Mechanism of Action Study

Arthritis Care &Research, EarlyView.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain, and magnetic resonance imaging–confirmed midfoot BMLs ...
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

Relating the Age of Arctic Sea Ice to its Thickness, as Measured during NASA’s ICESat and IceBridge Campaigns

Remote Sensing, 2016
Recent satellite observations yield estimates of the distribution of sea ice thickness across the entire Arctic Ocean. While these sensors were only placed in operation within the last few years, information from other sensors may assist us with ...
Mark A. Tschudi, Julienne C. Stroeve, J. Scott Stewart   +2 more
doaj   +1 more source