A modified iChip for in situ cultivation of bacteria in arid environments [PDF]
Applied and Environmental MicrobiologyAntimicrobial resistance is an ever-increasing problem for human health, and with only a few novel antimicrobials discovered in recent decades, an extraordinary effort is needed to circumvent this crisis.
Trine Bilde +2 more
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Use of modified ichip for the cultivation of thermo-tolerant microorganisms from the hot spring [PDF]
BMC Microbiology, 2023 Background Thermostable microorganisms are extremophiles. They have a special genetic background and metabolic pathway and can produce a variety of enzymes and other active substances with special functions.
Yasmeen Shakir, Deng Yulin
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Assessing Normandy Soil Microbial Diversity for Antibacterial Activities Using Traditional Culture and iChip Methods [PDF]
MicroorganismsUncultured microorganisms represent a promising and untapped source of antibacterial compounds, crucial in the fight against the significant threat of antimicrobial resistance (AMR).
Antoine Gery +2 more
exaly +7 more sources
Harnessing iChip technology for novel antibiotic discovery from peat soil microbiomes to combat antimicrobial resistance [PDF]
Frontiers in MicrobiologyChabib Lutfi
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Drug repurposing of natural depsipeptide from Eleftheria terrae isolated via iChip for anti-breast cancer therapy [PDF]
Frontiers in PharmacologyGraphical AbstractDiagram showing a drug development process using AI. Left panel depicts molecular structures of teixobactin and clovibactin. Middle section illustrates pharmacochemistry, ADMET pharmacokinetics, and pharmacodynamics targeting with ...
Nuriyatul Fhatonah +9 more
doaj +5 more sources
iChip increases the success of cultivation of TBT-resistant and TBT-degrading bacteria from estuarine sediment [PDF]
World Journal of Microbiology and Biotechnology, 2022 AbstractStandard methods of microbial cultivation only enable the isolation of a fraction of the total environmental bacteria. Numerous techniques have been developed to increase the success of isolation and cultivation in the laboratory, some of which derive from diffusion chambers. In a diffusion chamber, environmental bacteria in agar medium are put
Femi Olorunniji, Amélie Polrot
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Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity [PDF]
MoleculesThe discovery of new microbial metabolites is essential to combat the alarming rise in antimicrobial resistance and to meet emerging medical needs. This work critically reviews current strategies for identifying antimicrobial compounds, emphasizing the ...
Pablo Dasí-Delgado +2 more
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Early detection of aberrant cell fate and repair using circulating progenitor cells in patients with heterotopic ossification [PDF]
Nature CommunicationsHeterotopic ossification (HO), the abnormal formation of bone in soft tissues, is a debilitating complication that occurs after severe burns, trauma, and joint replacement surgery.
Johanna Nunez +19 more
doaj +2 more sources
Unlocking Microbial Dark Matter: A Comprehensive Review of Isolation Technologies from Traditional Culturing to Single-Cell Technologies [PDF]
MicroorganismsMicroorganisms represent the Earth’s most abundant biomass and a vast reservoir of genetic diversity. However, traditional agar plate methods fail to recover the vast majority of these species, leaving a “microbial dark matter” that holds immense ...
Xi Sun, Xiaoxuan Zhang, Jia Zhang
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Hanstruepera marina sp. nov. and Hanstruepera flava sp. nov., two novel species in the family Flavobacteriaceae isolated by a modified in situ cultivation technique from marine sediment [PDF]
Frontiers in Microbiology, 2022 A modified in situ cultivation technique was developed and applied to resource mining of uncultured microbes from marine sediments of Meishan Island in the East China Sea.
Hong Ding +6 more
doaj +2 more sources