Results 41 to 50 of about 42,839 (296)
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Neural mechanisms of the temporal response of cortical neurons to intracortical microstimulation
Brain StimulationBackground: Intracortical microstimulation (ICMS) is used to map neuronal circuitry in the brain and restore lost sensory function, including vision, hearing, and somatosensation.
Karthik Kumaravelu, Warren M. Grill
doaj +1 more source
Boletín de la Sociedad Española de Cerámica y Vidrio, 2021 In this work, novel 3 mol% yttria tetragonal zirconia polycristalline (3YTZP) ceramic composites with boron nitride nanosheets (BNNS) are investigated for the first time.
Carmen Muñoz-Ferreiro +3 more
doaj +1 more source
On the feasibility of semi-algebraic sets in Poisson regression
, 2016 Designing experiments for generalized linear models is difficult because optimal designs depend on unknown parameters. The local optimality approach is to study the regions in parameter space where a given design is optimal.
Kahle, Thomas
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A previously unreported coordination motif stabilising single Fe atoms by indigo chelation and pyridyl coordination on Au(111) has been revealed. By using planar tritopic pyridyl linkers (TPyB), extended 2D porous networks of indigo3(TPyB)2Fe6 form. These networks can be crystalline or vitreous and offer an environment where individual coordination ...
Hongxiang Xu +9 more
wiley +1 more source
Engineering transient dynamics of artificial cells by stochastic distribution of enzymes
Nature Communications, 2021 Here the authors develop a coacervate micromotor that can display autonomous motion as a result of stochastic distribution of propelling units. This stochastic-induced mobility is validated and explained through experiments and theory.
Shidong Song +10 more
doaj +1 more source
Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery [PDF]
, 2013 Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
A Demissie +68 more
core +2 more sources
Evolution in the Iron Abundance of the ICM [PDF]
Progress of Theoretical Physics Supplement, 2007 We present a Chandra analysis of the X-ray spectra of 56 clusters of galaxies at $z>0.3$, which cover a temperature range of $3> kT > 15$ keV. Our analysis is aimed at measuring the iron abundance in the ICM out to the highest redshift probed to date.
Balestra, I. +6 more
openaire +3 more sources