Results 41 to 50 of about 15,787 (297)

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Automated navigation of condensate phase behavior with active machine learning

Nature Communications
Biomolecular condensates are essential cellular structures formed via biomacromolecule phase separation. Synthetic condensates allow for systematic engineering and understanding of condensate formation mechanisms and to serve as cell-mimetic platforms ...
Yannick H. A. Leurs, Willem van den Hout, Andrea Gardin, Joost L. J. van Dongen, Andoni Rodriguez-Abetxuko, Nadia A. Erkamp, Jan C. M. van Hest, Francesca Grisoni, Luc Brunsveld   +8 more
doaj   +1 more source

Reflexões sobre o ICMS e sua repercussão nas empresas [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas. Programa de Pós-Graduação em DireitoO trabalho discute fundamentalmente a relação jurídico-funcional das empresas frente ao ICMS que, por sua natureza, é um ...
Ortigara, Eduardo Marozo
core  

A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment

Advanced Science, EarlyView.
The mechanobiological basis of atherosclerotic progression and its contribution to spatial and temporal heterogeneity remain incompletely understood. Spatially resolved AFM measurements revealed that plaque formation and distinct regions (cap fibrosis, intimal fibrosis, and lipid‐rich core) exhibit heterogeneous elastic modulus and viscoelastic ...
Yidan Zhou, Zhuo Chang, Xianjun Wu, Sijie Wang, Yuzhi Zhang, Hao Zhang, Haoyu Xu, Ruining Peng, Zhe Wang, Huiyun Xu, Yu Liu, Guangkui Xu, Nu Zhang, Hui Yang   +13 more
wiley   +1 more source

Engineering transient dynamics of artificial cells by stochastic distribution of enzymes

Nature Communications, 2021
Here the authors develop a coacervate micromotor that can display autonomous motion as a result of stochastic distribution of propelling units. This stochastic-induced mobility is validated and explained through experiments and theory.
Shidong Song, Alexander F. Mason, Richard A. J. Post, Marco De Corato, Rafael Mestre, N. Amy Yewdall, Shoupeng Cao, Remco W. van der Hofstad, Samuel Sanchez, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest   +10 more
doaj   +1 more source

Impactos da substituição tributária do ICMS sobre a carga tributária das empresas optantes pelo Simples Nacional: um estudo multicasos em duas empresas de Santa Catarina [PDF]

, 2011
TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Ciências Contábeis.As Micro Empresas - ME e as Empresas de Pequeno Porte - EPP enquadradas no Simples Nacional estão enfrentando alterações na legislação vigente ...
Bortolon, Bruna Raulino
core  

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Protected areas as criteria of Ecological ICMS in Brazilian states

Desenvolvimento e Meio Ambiente, 2020
O ICMS Ecológico é um instrumento econômico que tem sido apontado como uma importante estratégia de associação do incremento do orçamento municipal com a conservação da biodiversidade a partir da criação e manutenção de áreas protegidas.
Isabella Moura Carvalho Lima, Laura Jane Gomes, Milton Marques Fernandes   +2 more
doaj   +1 more source

Using a computationally driven screening to enhance magnetocaloric effect of metal monoborides

JPhys Energy, 2023
In most cases, substitution studies that aim to optimize magnetic properties are performed at the magnetic atomic site. However, in the case of MnB, magnetic substitutions at the Mn site significantly decrease the once promising magnetocaloric and ...
Carlos Romero-Muñiz, Jia Yan Law, Luis M Moreno-Ramírez, Álvaro Díaz-García, Victorino Franco   +4 more
doaj   +1 more source

A first insight into the microstructure and crack propagation in novel boron nitride nanosheet/3YTZP composites

Boletín de la Sociedad Española de Cerámica y Vidrio, 2021
In this work, novel 3 mol% yttria tetragonal zirconia polycristalline (3YTZP) ceramic composites with boron nitride nanosheets (BNNS) are investigated for the first time.
Carmen Muñoz-Ferreiro, Ana Morales-Rodríguez, Ángela Gallardo-López, Rosalía Poyato   +3 more
doaj   +1 more source