Results 61 to 70 of about 63,317 (307)
Advanced Healthcare Materials, EarlyView.Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns +10 more
wiley +1 more source
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, EarlyView.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
Organizational Primacy after the Demise of the Organizational Career: Employment Conflict in a Post-Standard Contract World [PDF]
, 2010 [Excerpt] There is a contradiction at the heart of dispute resolution in the contemporary workplace. The locus of determination of the terms and conditions of employment, including processes for the resolution of disputes concerning these terms and ...
Colvin, Alexander
core +1 more source
Advanced Science, EarlyView.Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi +10 more
wiley +1 more source
Nonproportional Intentionally Mistuned Turbine Blisk Design with Improved Component Modal Synthesis
Shock and Vibration, 2021 An improved component modal synthesis-based nonproportional mistuning method (ICMS-NPMM) is proposed to investigate mistuned turbine blisks (MTBs) since the high-fidelity finite element models (HFEMs) involve large number of computations, which leads to ...
Bin Bai +4 more
doaj +1 more source
, 2020 This document is a summary of Lakoff's idealized cognitive models. It describes the background and explains the model with some examples taken from Evans and Green's Cognitive linguistics (chapter 8). This document is in Persian.
openaire +1 more source
, 2007 This paper reports a qualitative assessment made at the sanitary landfill, recycling centers and composting units sponsored by the State Law No 13.803/2000, Minas Gerais, Brazil.
José Francisco do Prado Filho +1 more
semanticscholar +1 more source
Advanced Science, EarlyView.Phase separation organizes cellular components, yet stabilizing such dynamic structures in artificial cells remains challenging. A photo‐crosslinking approach is presented that prolongs the lifetime of different structures in coacervate‐based artificial cells while maintaining dynamic formation.
Madelief A. M. Verwiel +4 more
wiley +1 more source
Automated navigation of condensate phase behavior with active machine learning
Nature CommunicationsBiomolecular condensates are essential cellular structures formed via biomacromolecule phase separation. Synthetic condensates allow for systematic engineering and understanding of condensate formation mechanisms and to serve as cell-mimetic platforms ...
Yannick H. A. Leurs +8 more
doaj +1 more source