Results 1 to 10 of about 58,529 (150)

Cost-effectiveness analysis of a single-inhaler triple therapy for COPD in the UK

ERJ Open Research, 2021
UK management costs for COPD, estimated at £1.9 billion/year, are rising. In the FULFIL (Lung Function and Quality of Life Assessment in Chronic Obstructive Pulmonary Disease with Closed Triple Therapy) study, single-inhaler triple therapy with ...
Elisabeth Fenwick, Alan Martin, Melanie Schroeder, Stuart J. Mealing, Oyinkansola Solanke, Nancy Risebrough, Afisi S. Ismaila   +6 more
doaj   +1 more source

Does scrolling affect measurement equivalence of electronic patient-reported outcome measures (ePROM)? Results of a quantitative equivalence study

Journal of Patient-Reported Outcomes, 2021
Background Scrolling is a perceived barrier in the use of bring your own device (BYOD) to capture electronic patient reported outcomes (ePROs). This study explored the impact of scrolling on the measurement equivalence of electronic patient-reported ...
Saeid Shahraz, Tan P. Pham, Marc Gibson, Marie De La Cruz, Munther Baara, Sachin Karnik, Christopher Dell, Sheryl Pease, Suyash Nigam, Joseph C. Cappelleri, Craig Lipset, Patrick Zornow, Jeff Lee, Bill Byrom   +13 more
doaj   +1 more source

Rethinking, reducing, and refining the classical oral tyramine challenge test of monoamine oxidase (MAO) inhibitors

Clinical and Translational Science, 2023
The oral tyramine challenge evaluates the safety of novel monoamine oxidase (MAO) inhibitors when taken with tyramine‐containing food or drinks. In its current design, it comprises an extensive series of tyramine escalation steps until a blood pressure ...
Ewoud‐Jan vanHoogdalem, Karen L. Smith, Jan Hartstra, John Constant   +3 more
doaj   +1 more source

Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework

Frontiers in Immunology, 2023
IntroductionDespite representing only 3% of the US population, immunocompromised (IC) individuals account for nearly half of the COVID-19 breakthrough hospitalizations. IC individuals generate a lower immune response after vaccination in general, and the
Xuan Wang, Katrin Haeussler, Anne Spellman, Leslie E. Phillips, Allison Ramiller, Mary T. Bausch-Jurken, Pawana Sharma, Anna Krivelyova, Sonam Vats, Nicolas Van de Velde   +9 more
doaj   +1 more source

Indirect Comparison of Lanadelumab and Intravenous C1-INH Using Data from the HELP and CHANGE Studies: Bayesian and Frequentist Analyses

Drugs in R&D, 2021
Background Hereditary angioedema (HAE) with C1-esterase inhibitor (C1-INH) deficiency is a rare disease associated with painful, potentially fatal swelling episodes affecting subcutaneous or submucosal tissues.
Joan Mendivil, Mia Malmenäs, Katrin Haeussler, Matthias Hunger, Gagan Jain, Giovanna Devercelli   +5 more
doaj   +1 more source

Psychometric properties of the Alzheimer’s Disease Cooperative Study – Activities of Daily Living for Mild Cognitive Impairment (ADCS-MCI-ADL) scale: a post hoc analysis of the ADCS ADC-008 trial

BMC Geriatrics, 2023
Background The Alzheimer's Disease Cooperative Study – Activities of Daily Living Scale for use in Mild Cognitive Impairment (MCI), the ADCS-ADL-MCI, is an evaluation scale with information provided by an informant/caregiver to describe the functional ...
Michele Potashman, Menglan Pang, Muna Tahir, Saeid Shahraz, Sascha Dichter, Robert Perneczky, Sandra Nolte   +6 more
doaj   +1 more source

Cost-effectiveness of umeclidinium compared with tiotropium and glycopyrronium as monotherapy for chronic obstructive pulmonary disease: a UK perspective

Cost Effectiveness and Resource Allocation, 2018
Background Cost-effectiveness of once-daily umeclidinium bromide (UMEC) was compared with once-daily tiotropium (TIO) and once-daily glycopyrronium (GLY) in patients with chronic obstructive pulmonary disease (COPD) from a UK National Health Service (NHS)
Dhvani Shah, Maurice Driessen, Nancy Risebrough, Timothy Baker, Ian Naya, Andrew Briggs, Afisi S. Ismaila   +6 more
doaj   +1 more source

Dose-escalated radiotherapy to 82 Gy for prostate cancer following insertion of a peri-rectal hydrogel spacer: 3-year outcomes from a phase II trial

Radiation Oncology, 2022
Background Dose-escalation to above 80 Gy during external beam radiotherapy for localised prostate cancer leads to improved oncological outcomes but also substantially increased rectal toxicity.
Andrew W. See, Patrick Bowden, Geoffrey Wells, Sree Appu, Nathan Lawrentschuk, Peter Liodakis, Chloe Pandeli, Yolanda Aarons, Lloyd M. L. Smyth, Dean P. McKenzie   +9 more
doaj   +1 more source

Power Spiral Enteroscopy: A Quick and Powerful Dive Deep Inside the Small Bowel!

Journal of Digestive Endoscopy, 2022
A comprehensive and detailed small bowel evaluation became possible since 2001 with the advent of a wireless capsule endoscope that was primarily used for diagnostic purposes.
Chalapathi Rao Achanta, Vasanthika Imandi, Sudhanva V. Kinhal, Sridhar Sundharam, Manas Panigrahi, Sneha Shanthi Didchela, Swetha Hanumanthu, Raja Mahesh Kunchala, Amninder Singh   +8 more
doaj   +1 more source

Development and Validation of a Canine Health-Related Quality of Life Questionnaire and a Human–Canine Bond Questionnaire for Use in Veterinary Practice

Animals, 2023
The use of valid questionnaires to assess dogs’ health-related quality of life (HRQoL) in veterinary practice can improve canine health outcomes and communications between veterinarians and caretakers of dogs. The Canine HRQoL Questionnaire (Canine HRQoL-
Robert P. Lavan, Muna Tahir, Christina O’Donnell, Alex Bellenger, Elodie de Bock, Patricia Koochaki   +5 more
doaj   +1 more source