Results 21 to 30 of about 450,172 (307)

Indirect Comparison of Lanadelumab and Intravenous C1-INH Using Data from the HELP and CHANGE Studies: Bayesian and Frequentist Analyses

Drugs in R&D, 2021
Background Hereditary angioedema (HAE) with C1-esterase inhibitor (C1-INH) deficiency is a rare disease associated with painful, potentially fatal swelling episodes affecting subcutaneous or submucosal tissues.
Joan Mendivil, Mia Malmenäs, Katrin Haeussler, Matthias Hunger, Gagan Jain, Giovanna Devercelli   +5 more
doaj   +1 more source

Dose-escalated radiotherapy to 82 Gy for prostate cancer following insertion of a peri-rectal hydrogel spacer: 3-year outcomes from a phase II trial

Radiation Oncology, 2022
Background Dose-escalation to above 80 Gy during external beam radiotherapy for localised prostate cancer leads to improved oncological outcomes but also substantially increased rectal toxicity.
Andrew W. See, Patrick Bowden, Geoffrey Wells, Sree Appu, Nathan Lawrentschuk, Peter Liodakis, Chloe Pandeli, Yolanda Aarons, Lloyd M. L. Smyth, Dean P. McKenzie   +9 more
doaj   +1 more source

Power Spiral Enteroscopy: A Quick and Powerful Dive Deep Inside the Small Bowel!

Journal of Digestive Endoscopy, 2022
A comprehensive and detailed small bowel evaluation became possible since 2001 with the advent of a wireless capsule endoscope that was primarily used for diagnostic purposes.
Chalapathi Rao Achanta, Vasanthika Imandi, Sudhanva V. Kinhal, Sridhar Sundharam, Manas Panigrahi, Sneha Shanthi Didchela, Swetha Hanumanthu, Raja Mahesh Kunchala, Amninder Singh   +8 more
doaj   +1 more source

Iconic semiosis and representational efficiency in the London Underground Diagram [PDF]

, 2014
The icon is the type of sign connected to efficient representational features, and its manipulation reveals more information about its object. The London Underground Diagram (LUD) is an iconic artifact and a well-known example of representational ...
Atã, Pedro, Bitarello, Breno, Queiroz, Joao   +2 more
core   +1 more source

To what degree are orphan drugs patient-centered? A review of the current state of clinical research in rare diseases

Orphanet Journal of Rare Diseases, 2020
Background Over the past 30 years, the healthcare industry has increasingly turned its attention to rare diseases. Regulators have emphasized the need for clinical research in this area to be patient-centered.
Sally Lanar, Catherine Acquadro, James Seaton, Isabelle Savre, Benoit Arnould   +4 more
doaj   +1 more source

Is Simpler Always Better? Consumer Evaluations of Front-of-Package Nutrition Symbols [PDF]

, 2011
Consumers of packaged goods products in the United States recently have faced an onslaught of front-of-package (FOP) nutrition symbols and icons, including the controversial “Smart Choices” single summary indicator.
Andrews, J. Craig, Burton, Scot, Kees, Jeremy   +2 more
core   +3 more sources

Dose reduction to organs at risk with deep-inspiration breath-hold during right breast radiotherapy: a treatment planning study

Radiation Oncology, 2019
Background The addition of regional nodal radiation (RNI) to whole breast irradiation for high risk breast cancer improves metastases free survival and new data suggests it contributes additional benefit to overall survival. Deep inspiration breath hold (
Chloe Pandeli, Lloyd M. L. Smyth, Steven David, Andrew W. See   +3 more
doaj   +1 more source

Subband decomposition techniques for adaptive channel equalisation [PDF]

, 2005
In this contribution, the convergence behaviour of the adaptive linear equaliser based on subband decomposition technique is investigated. Two different subband-based linear equalisers are employed, with the aim of improving the equaliser's convergence ...
Alias, Mohamad Yusoff, Arif, Nor Azhar Mohd, Mohamad, Hafizal, Weiss, Stephan   +3 more
core   +1 more source

Cost-effectiveness analysis of umeclidinium bromide/vilanterol 62.5/25 mcg versus tiotropium/olodaterol 5/5 mcg in symptomatic patients with chronic obstructive pulmonary disease: a Spanish National Healthcare System perspective

Respiratory Research, 2018
Background A head-to-head study demonstrated the superiority of once-daily umeclidinium bromide/vilanterol (UMEC/VI) 62.5/25 mcg on trough forced expiratory volume in 1 s (FEV1) versus once-daily tiotropium/olodaterol (TIO/OLO) 5/5 mcg in symptomatic ...
M. T. Driessen, J. Whalen, B. Seewoodharry Buguth, L. A. Vallejo-Aparicio, I. P. Naya, Y. Asukai, B. Alcázar-Navarrete, M. Miravitlles, F. García-Río, N. A. Risebrough   +9 more
doaj   +1 more source

Content validation and psychometric evaluation of the Angioedema Quality of Life Questionnaire for hereditary angioedema

Journal of Patient-Reported Outcomes, 2023
Background There is considerable burden of illness in hereditary angioedema (HAE). However, instruments to assess health-related quality of life (HRQoL) in HAE are limited.
Magdalena Vanya, Maureen Watt, Saeid Shahraz, Charlotte E. Kosmas, Stephanie Rhoten, Sara Costa-Cabral, Joan Mendivil, Giovanna Devercelli, Karsten Weller   +8 more
doaj   +1 more source