Results 111 to 120 of about 450,172 (307)

Icones Aroidearum,

Heinrich Wilhelm Schott (1794-1865), botanist and gardener. Born at Brno (today: Czech Republic) January 7th 1794, died at Schönbrunn (today within the city of Vienna, Austria) March 5th 1865, son of the gardener Heinrich Schott (1759-1819).- Schott attended botanical lectures of Nikolaus Joseph von Jacquin (1727-1817) and Joseph Franz von Jacquin ...
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Space and time in words: exploring neural overlap and specificity

Behavioral and Brain Functions
Background A common magnitude system—consistently involving the right intraparietal sulcus (IPS)—has been proposed to support the representation of space, time and numerosity.
Francesca Conca, Giulia Mattavelli, Claudia Gianelli, Nicola Canessa, Eleonora Catricalà   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Functional outcomes and toxicity following focal low‐dose‐rate brachytherapy for low–intermediate risk prostate cancer

BJUI Compass
Objectives We aim to prospectively evaluate functional outcomes and toxicity following focal low‐dose‐rate (LDR) brachytherapy for low–intermediate risk prostate cancer (PCa). Patients and Methods LIBERATE is a clinical registry of men treated with focal
Mohammadmehdi Adhami, Jeremy Cheng, Elliot Anderson, Lloyd Smyth, Cate Davey, Thang Nguyen, Richard O'Sullivan, Andrew Ryan, Nathan Lawrentschuk, Jeremy Grummet, Andrew See   +10 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Quantifying the Multidimensionality of Abstract Concepts: An Italian Database

Brain Sciences
Background: The embodied cognition approach, as applied to concrete knowledge, is centred on the role of the perceptual and motor aspects of experience.
Virginia Maria Borsa, Maria Arioli, Riccardo Verni, Nicola Canessa, Stefano F. Cappa, Eleonora Catricalà   +5 more
doaj   +1 more source

icon: web icons for rmarkdown

, 2018
🔗Icons in R Icons can be added to your R Markdown documents using short prefixes which identify the font’s library.fa: Font Awesomeai: Academiconsii: ionicons For example, `r icon::fa("rocket")` can be used to add the rocket icon from Font Awesome.
openaire   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source