Results 91 to 100 of about 127,559 (313)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Evaluation of the spatial impacts of improved connectivity from urban transport investments. A GIS (Geographic Information System) application of the ICON indicator for urban areas. [PDF]

open access: yes
A well-designed urban public transport policy provides significant benefits: reduces congestion and costs, and decreases the number of accidents and environment impacts. Accessibility indicators are used by planners to assess the spatial effects of their
Hector Tapia, Mateu Turró
core  

Polyp Endotherapy for Multiple Jejunal Lipomas Presenting as Small Bowel Intussusception: “Loop and Let Go Technique”

open access: yesJournal of Digestive Endoscopy
A 46-year-old woman presented with abdominal pain, vomiting, and intermittent constipation for the last 2 days. She had similar history of recurrent symptoms for the last 6 months.
Chalapathi R. Achanta   +1 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

What made you realise that you wanted to be a conservator?

open access: yes
Plowden Medal 2021 winner and Icon member Professor Jane Henderson ACR talks about teaching, accreditation, success, and her hopes for the ...
Henderson, Jane, Icon
core  

The Evolution of Nancy Drew, Cultural Icon: Readers, Writers, and Fanfiction Authors

open access: yes, 2007
Nancy Drew is widely recognized as an influential American cultural icon. In this paper I make a detailed examination of Nancy's initial characterization as girl sleuth in the first ten books of the Nancy Drew Mystery Stories, published in the 1930s.
Merrill, Ashley
core  

An Evaluation of Mental Health First Aid Officer Utilisation Across an International, Interdisciplinary Oncology Group

open access: yesJournal of Medical Radiation Sciences
Introduction Mental health is a critical component of overall well‐being, yet healthcare professionals, particularly those in oncology, face unique stressors that increase their risk of compassion fatigue and burnout.
Janeane Summerfield, Aidan Leong
doaj   +1 more source

Cancer Patients Missing Pain Score Information:- Application with Imputation Techniques

open access: yesEpidemiology, Biostatistics and Public Health, 2022
Background: Methods for handling missing data in clinical research have been getting more attentions over last few years. Contemplation of missing data in any study is vital as they may lead to considerable biases and can have an impact on the power of ...
Gajendra Vishwakarma   +3 more
doaj  

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