Results 81 to 90 of about 146,661 (248)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Space and time in words: exploring neural overlap and specificity

Behavioral and Brain Functions
Background A common magnitude system—consistently involving the right intraparietal sulcus (IPS)—has been proposed to support the representation of space, time and numerosity.
Francesca Conca, Giulia Mattavelli, Claudia Gianelli, Nicola Canessa, Eleonora Catricalà   +4 more
doaj   +1 more source

Polyp Endotherapy for Multiple Jejunal Lipomas Presenting as Small Bowel Intussusception: “Loop and Let Go Technique”

Journal of Digestive Endoscopy
A 46-year-old woman presented with abdominal pain, vomiting, and intermittent constipation for the last 2 days. She had similar history of recurrent symptoms for the last 6 months.
Chalapathi R. Achanta, Sudhanva V. Kinhal   +1 more
doaj   +1 more source

Furnace, Moss Icon, Yesterday's Parade and Circle concert flier, Baldwin Hall, Annapolis, Maryland, April 29, 1988

, 1988
Flier promoting a concert with the punk bands Yesterday's Parade, Furnace, Moss Icon, and Circle.

core  

Hourly ICON outputs from irrigation sensitivity test

Irrigation is an agricultural practice that keeps an ideal soil moisture for crop growth. Aside from this, the Earth system community also recognized the irrigation impact on different components of the Earth system.
Arianna Valmassoi, Roque Mamani, Jane Leonor   +1 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Oncological outcomes post focal low‐dose‐rate brachytherapy in low‐intermediate risk prostate cancer

BJUI Compass
Objectives To prospectively evaluate oncological control, pathological progression, and its predictors following focal low‐dose‐rate (LDR) brachytherapy for low‐intermediate risk prostate cancer (PCa).
Mohammadmehdi Adhami, Jeremy Cheng, Elliot Anderson, Lloyd Smyth, Cate Davey, Thang Nguyen, Richard O'Sullivan, Andrew Ryan, Nathan Lawrentschuk, Jeremy Grummet, Andrew See   +10 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer Patients Missing Pain Score Information:- Application with Imputation Techniques

Epidemiology, Biostatistics and Public Health, 2022
Background: Methods for handling missing data in clinical research have been getting more attentions over last few years. Contemplation of missing data in any study is vital as they may lead to considerable biases and can have an impact on the power of ...
Gajendra Vishwakarma , Atanu Bhattacharjee, Jesna Jose, Ramesh Kumar V   +3 more
doaj