Results 81 to 90 of about 127,559 (313)
Iterative process of design and evaluation of icons for menu structure interface of interactive TV services [PDF]
, 2006 http://www.tandfonline.com/doi/full/10.1080/01449290500167832#.UqHyfoGZ_7oThis paper shows an iterative process of design and evaluation of icons for future interactive TV services.
LIM, Dokshin, BOUCHARD, Carole
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Oral History of Icon Sebastian Escada
, 2019 Icon Sebastian Escada describes the founding of the first ballroom house in Atlanta, the responsibilities of being a house mother, and his invention of the “realness with a twist” category.
Escada, Icon Sebastian
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[sound icon], March 17, 2014 [PDF]
, 2014 This is the concert program of the [sound icon] performance on Monday, March 17, 2014 at 8:00 p.m., at the Boston University Concert Hall, 855 Commonwealth Avenue, Boston, Massachusetts.
School of Music, Boston University
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oral History of Icon Peanut Revlon
, 2019 Icon Peanut Revlon talks about his entrance into Baltimore’s ballroom scene as a teenager at Club Bunns, the chosen family relationships he formed in the ballroom community, and why ballroom is important to him as a form of personal and creative ...
Revlon, Icon Peanut
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Oncological outcomes post focal low‐dose‐rate brachytherapy in low‐intermediate risk prostate cancer
BJUI CompassObjectives To prospectively evaluate oncological control, pathological progression, and its predictors following focal low‐dose‐rate (LDR) brachytherapy for low‐intermediate risk prostate cancer (PCa).
Mohammadmehdi Adhami +10 more
doaj +1 more source