Results 81 to 90 of about 450,172 (307)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Children's interactions with interactive toy technology [PDF]
, 2003 Digital toys offer the opportunity to explore software scaffolding through tangible interfaces that are not bound to the desktop computer. This paper describes the empirical work completed by the CACHET (Computers and Children's Electronic Toys) project ...
Airey, S. +3 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
BMC Research Notes, 2017 Background The purpose of this study is to develop patient-reported (PRO) and observer-reported (ObsRO) outcome measures of ulcerative colitis (UC) signs/symptoms in children aged 5–17 with mild/moderate UC.
Emuella Flood +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Notes on Nightingale: The Influence and Legacy of a Nursing Icon [PDF]
, 2010 {Excerpt}The centenary of the death of Florence Nightingale occurs on 13 August 2010. Like Charles Darwin, Charles Dickens, and John Stuart Mill, Nightingale is one of those monumental Victorians who were genuine household names in their day and for the ...
Nelson, Sioban, Rafferty, Anne Marie
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Faktor Pemanfaatan Imunisasi Inactivated Polio Vaccine (IPV)
Jurnal Kesehatan, 2020 The low utilization of IPV immunization services in Palembang in 2017 was 66,7% while the national target was 95%. The purpose of this study was to determine the factors associated with the utilization of IPV immunization services in Palembang. The study
Icon Harizon +2 more
doaj +1 more source
, 2008 The iPod became, for a moment at least, iconic amongst those hand-held electronic devices with buttons and screens, noises and "connectivity" that proliferated at the beginning of the twenty-first century. This essay explores how the iPod, in becoming an unobtrusive memory machine as absent as an internal organ on the body of its user, provides a ...
openaire +2 more sources
Iconics: Icon Evolution in Digitality
tripleC: Communication, Capitalism & Critique. Open Access Journal for a Global Sustainable Information Society, 2010 Image manipulation, archiving, and sharing are all critical technological aspects of Western culture and postmodern civilization. Consequently, creation, identification, dissemination, and proliferation of powerful images across media channels today indicate a burgeoning area of information technology.While words alone are capable of conveying adequate
openaire +3 more sources