Results 11 to 20 of about 117,111 (323)

Comprehensive analysis of the role of ICOS ( CD278 ) in pan-cancer prognosis and immunotherapy

BMC Cancer, 2023
Background The immunological checkpoint known as Inducible T Cell Costimulatory Factor (ICOS, Cluster of Differentiation, CD278) is activated and expressed on T cells. Both somatic cells and antigen-presenting cells expressed its ligand, ICOSL (including
Xiashuang Zhao, Yongfeng Wang, Xianglai Jiang, Bangqian Mo, Chenyu Wang, Mingzheng Tang, Yao Rong, Guiqian Zhang, Ming Hu, Hui Cai   +9 more
doaj   +2 more sources

ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases

Frontiers in Immunology, 2020
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) cells.
Dan-Yang Li, Dan-Yang Li, Xian-Zhi Xiong, Xian-Zhi Xiong   +3 more
doaj   +2 more sources

The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

Epigenetics, 2020
CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich   +9 more
doaj   +2 more sources

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Nature Communications, 2020
The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, binding its ligand (ICOS-L) on activated T cells. The structure of the ICOS/ICOS-L complex reveals a distinct receptor binding orientation.
Edurne Rujas, Hong Cui, Taylor Sicard, Anthony Semesi, Jean-Philippe Julien   +4 more
doaj   +2 more sources

ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis

Frontiers in Immunology, 2022
Inducible T cell co-stimulator (ICOS), an immune checkpoint protein expressed on activated T cells and its unique ligand, ICOSL, which is expressed on antigen-presenting cells and non-hematopoietic cells, have been extensively investigated in the immune ...
Gustavo Ferreira Alves, Ian Stoppa, Eleonora Aimaretti, Chiara Monge, Raffaella Mastrocola, Elisa Porchietto, Giacomo Einaudi, Debora Collotta, Ilaria Bertocchi, Elena Boggio, Casimiro Luca Gigliotti, Nausicaa Clemente, Manuela Aragno, Daniel Fernandes, Carlo Cifani, Christoph Thiemermann, Chiara Dianzani, Umberto Dianzani, Massimo Collino   +18 more
doaj   +2 more sources

Inducible Co-Stimulator ICOS Expression Correlates with Immune Cell Infiltration and Can Predict Prognosis in Lung Adenocarcinoma

International Journal of General Medicine, 2022
Gujie Wu,1,* Min He,1,* Kuan Ren,1,* Huiyun Ma,1 Qun Xue2 1Medical School of Nantong University, Nantong, People’s Republic of China; 2Cardiothoracic Surgery Department, Affiliated Hospital of Nantong University, Nantong, People’s Republic of
Wu G, He M, Ren K, Ma H, Xue Q
doaj   +2 more sources

Long-term daily hydrometeorological drought indices, soil moisture, and evapotranspiration for ICOS sites

Scientific Data, 2023
Eddy covariance sites are ideally suited for the study of extreme events on ecosystems as they allow the exchange of trace gases and energy fluxes between ecosystems and the lower atmosphere to be directly measured on a continuous basis.
F. Pohl, O. Rakovec, C. Rebmann, A. Hildebrandt, F. Boeing, Floris Hermanns, S. Attinger, L. Samaniego, Rohini Kumar   +8 more
semanticscholar   +1 more source

Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice

Journal of Neuroinflammation, 2023
Chemotherapy-induced peripheral neuropathy (CIPN) is a primary dose-limiting side effect caused by antineoplastic agents, such as paclitaxel. A primary symptom of this neuropathy is pain.
Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Juliet M. Mwirigi, G. Mejia, M. Burton, Theodore John Price   +5 more
semanticscholar   +1 more source

Targeting the Inducible T-cell Costimulator (ICOS) in patients with Relapsed/Refractory T-Follicular Helper Phenotype Peripheral T-Cell and Angioimmunoblastic T-Cell Lymphoma.

Clinical Cancer Research, 2023
PURPOSE Proliferation of T-follicular helper (TFH) CD4+ T-cells is a postulated pathogenic mechanism for T-cell non-Hodgkin's lymphomas (T-NHL). The inducible T-cell costimulator (ICOS) is highly expressed by TFH, representing a potential target.
J. Chavez, F. Foss, B. William, J. Brammer, Sonali M. Smith, A. Prica, J. Zain, J. Tuscano, H. Shah, N. Mehta-Shah, P. Ramakrishnan Geethakumari, Ben X Wang, Stephanie Zantinge, Lisa Wang, Ling Zhang, A. Boutrin, Weiguang Zhao, Lily I. Cheng, N. Standifer, L. Hewitt, Enowmpey Enowtambong, Weiping Shao, Shringi Sharma, G. Carlesso, J. Moscow, L. Siu   +25 more
semanticscholar   +1 more source

Differential Modulation of Human M1 and M2 Macrophage Activity by ICOS-Mediated ICOSL Triggering

International Journal of Molecular Sciences, 2023
Activated T cells express the inducible T-cell co-stimulator (ICOS) that, upon binding to its ubiquitously expressed ligand (ICOSL), regulates the immune response and tissue repair.
C. L. Gigliotti, C. Dianzani, I. Stoppa, Chiara Monge, S. Sutti, D. Sblattero, C. Puricelli, R. Rolla, U. Dianzani, E. Boggio   +9 more
semanticscholar   +1 more source