Results 21 to 30 of about 117,111 (323)

PD-1 and ICOS coexpression identifies tumor-reactive CD4+ T cells in human solid tumors

Journal of Clinical Investigation, 2022
CD4+ Th cells play a key role in orchestrating immune responses, but the identity of the CD4+ Th cells involved in the antitumor immune response remains to be defined.
Rebekka Duhen, Olivier Fesneau, K. Samson, Alexandra K. Frye, Michael Beymer, V. Rajamanickam, David Ross, E. Tran, Brady Bernard, A. Weinberg, Thomas Duhen   +10 more
semanticscholar   +1 more source

First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response

Clinical Cancer Research, 2022
Purpose: The first-in-human phase I/II ICONIC trial evaluated an investigational inducible costimulator (ICOS) agonist, vopratelimab, alone and in combination with nivolumab in patients with advanced solid tumors.
T. Yap, J. Gainor, M. Callahan, G. Falchook, R. Pachynski, P. Lorusso, S. Kummar, G. Gibney, H. Burris, S. Tykodi, O. Rahma, T. Seiwert, K. Papadopoulos, Mariela Blum Murphy, Haeseong Park, A. Hanson, Yasmin Hashambhoy-Ramsay, L. McGrath, E. Hooper, Xiaoying Xiao, H. Cohen, M. Fan, Daniel Felitsky, C. Hart, Rachel McComb, K. Brown, A. Sepahi, J. Jimenez, Weidong Zhang, J. Baeck, H. Laken, Richard Murray, E. Trehu, Christopher J Harvey   +33 more
semanticscholar   +1 more source

Initial coin offerings (ICOs): Why do they succeed?

Financial Innovation, 2022
Recent literature has addressed initial coin offering (ICO) projects, which are an innovative form of venture financing through cryptocurrencies using blockchain technology.
J. Campino, A. Brochado, Álvaro Rosa
semanticscholar   +1 more source

Paeoniflorin improves autoimmune myocarditis in young rat by inhibiting CXCR5 to reduce follicular helper T cells

Autoimmunity, 2022
In the current study, we aimed to investigate the effect of paeoniflorin on autoimmune myocarditis. A total of 72 young Lewis rats were randomly divided into control, experimental autoimmune myocarditis (EAM), paeoniflorin low dose (Pae-L 20 mg/kg ...
Chunxiao Wang, Lanlan Wang, Li Wang
doaj   +1 more source

Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction

Communications Biology, 2022
Immunofibroblasts have been described within tertiary lymphoid structures (TLS) that regulate lymphocyte aggregation at sites of chronic inflammation.
S. Nayar, E. Pontarini, J. Campos, O. Berardicurti, Charlotte G. Smith, Saba Asam, D. Gardner, S. Colafrancesco, D. Lucchesi, R. Coleby, M. Chung, V. Iannizzotto, K. Hunter, S. Bowman, G. Carlesso, R. Herbst, H. McGettrick, J. Browning, C. Buckley, B. Fisher, M. Bombardieri, F. Barone   +21 more
semanticscholar   +1 more source

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

Arthritis Research & Therapy, 2022
Background Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by generalized fibrosis affecting particularly the lungs and skin. Costimulatory molecules are
C. Orvain, A. Cauvet, A. Prudent, C. Guignabert, R. Thuillet, M. Ottaviani, L. Tu, Fanny Duhalde, C. Nicco, F. Batteux, J. Avouac, Ningxin Wang, M. Seaberg, S. Dillon, Y. Allanore   +14 more
semanticscholar   +1 more source

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis

Journal of Lipid Research, 2005
This study assessed the effects of selective inhibitors of 3′,5′-cyclic nucleotide phosphodiesterases (PDEs) on adipocyte lipolysis. IC224, a selective inhibitor of type 1 phosphodiesterase (PDE1), suppressed lipolysis in murine 3T3-L1 adipocytes (69.6 ±
Peter B. Snyder, James M. Esselstyn, Kate Loughney, Sharon L. Wolda, Vincent A. Florio   +4 more
doaj   +1 more source

RGIFE: a ranked guided iterative feature elimination heuristic for the identification of biomarkers

BMC Bioinformatics, 2017
Background Current -omics technologies are able to sense the state of a biological sample in a very wide variety of ways. Given the high dimensionality that typically characterises these data, relevant knowledge is often hidden and hard to identify ...
Nicola Lazzarini, Jaume Bacardit
doaj   +1 more source

Multiple in vitro and in vivo regulatory effects of budesonide in CD4+ T lymphocyte subpopulations of allergic asthmatics. [PDF]

, 2012
BACKGROUND: Increased activation and increased survival of T lymphocytes characterise bronchial asthma. OBJECTIVES: In this study the effect of budesonide on T cell survival, on inducible co-stimulator T cells (ICOS), on Foxp3 and on IL-10 molecules ...
Albeggiani, G, Bousquet, J, Di Sano, C, DI VINCENZO, Serena, Ferraro, M, Gjomarkaj, M., LA GRUTTA, Stefania, Liotta, G, Pace, E, Uasuf, CG   +9 more
core   +3 more sources

ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells

Life Science Alliance, 2022
ICOS signaling promotes T follicular regulatory cell differentiation during germinal center reaction safeguarding against autoantibody production. ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of
Vincent Panneton, Barbara C. Mindt, Y. Bouklouch, A. Bouchard, Saba Mohammaei, Jinsam Chang, Nikoletta Diamantopoulos, Mariko Witalis, Joanna Li, Albert Stancescu, J. Bradley, T. Randall, Jörg H Fritz, Woong-Kyung Suh   +13 more
semanticscholar   +1 more source