Results 41 to 50 of about 117,111 (323)

Eddy covariance raw data processing for CO2 and energy fluxes calculation at ICOS ecosystem stations [PDF]

, 2019
open18siThe eddy covariance is a powerful technique to estimate the surface-Atmosphere exchange of different scalars at the ecosystem scale. The EC method is central to the ecosystem component of the Integrated Carbon Observation System, a monitoring ...

core   +1 more source

Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.

JCI Insight, 2018
Successful tumor eradication by chimeric antigen receptor-expressing (CAR-expressing) T lymphocytes depends on CAR T cell persistence and effector function.
S. Guedan, A. Posey, Carolyn E Shaw, A. Wing, Tong Da, Prachi R Patel, S. McGettigan, Victoria Casado-Medrano, O. Kawalekar, M. Uribe-Herranz, Decheng Song, J. Melenhorst, S. Lacey, J. Scholler, B. Keith, R. Young, Carl H. June   +16 more
semanticscholar   +1 more source

Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing

Molecules, 2023
Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable human-based safety assessment in drug development. Intrahepatic cholangiocyte organoids (ICOs) are described as a donor-derived in vitro model for disease ...
Manon C. Bouwmeester, Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer, Bart Spee   +11 more
doaj   +1 more source

Polyfunctional Melan-A-specific tumor-reactive CD8+ T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS [PDF]

, 2016
The identification of activation pathways linked to anti-tumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy.
Belinda, Palermobc, Cosmo Di, Donnac, GISMONDI, Angela, Isabella, Sperdutid, Ornella, Franzesea, SANTONI, Angela, STABILE, MARIA HELENA, Virginia, Ferraresie   +7 more
core   +1 more source

Altered Phenotypes of Colonic and Peripheral Blood Follicular Helper and Follicular Cytotoxic T Cells in Mice with DSS-Induced Colitis

Journal of Inflammation Research, 2023
Yan Long, Chang-Sheng Xia, Xingyue Zeng, Jinghong Feng, Yinting Ma, Chen Liu Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yan Long; Chen Liu, Department of Clinical Laboratory,
Long Y, Xia CS, Zeng X, Feng J, Ma Y, Liu C   +5 more
doaj  

Fundraising Campaigns in a Digital Economy: Lessons from a Swiss Synthetic Diamond Venture's Initial Coin Offering (ICO)

Technology Innovation Management Review, 2020
As economies digitalize and many local businesses gradually internationalize, crowdfunding platforms have offered a new way for ventures to raise capital.
Jahja Rrustemi, Nils S. Tuchschmid
doaj   +1 more source

Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling. [PDF]

PLoS ONE, 2012
We previously showed that mice deficient in the Inducible Costimulator ligand (ICOSL-KO) develop more severe disease and lung pathology with delayed bacterial clearance upon respiratory infection of Chlamydia muridarum.
Xiaoling Gao, Mathieu Gigoux, Jie Yang, Julien Leconte, Xi Yang, Woong-Kyung Suh   +5 more
doaj   +1 more source

Immunoregulatory gene polymorphisms in women with preeclampsia [PDF]

, 2011
The costimulatory molecules CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4) (cytotoxic T-lymphocyte-associated antigen-4) and inducible costimulator (ICOS) are believed to have a critical modulatory role in the immune response.
A Ohkuchi, A Samsami Dehaghani, AD Allaire, AF Tsai, Antonio F Moron, B Huppertz, B Sibai, C Hirashima, Camila S Franchim, CT Roberts, CW Redman, DS Cunninghame Graham, E Fitzpatrick, E Jaaskelainen, F Flores-Borja, K Douroudis, K Harper, Karen P T Pendeloski, KS Khan, LM Bodnar, LR Guerin, M Maurer, Maria R Torloni, Nelson Sass, NHBPEP, OP Kristiansen, P de Reuver, RA Shilling, Rosiane Mattar, RV Santos, S Daher, S Gustincich, S Saito, SDJ Pena, Silvia Daher, ST Chelbi, T Kaartinen, T Kouki, T Takahashi, VB Guzman, WD Dupont, X Wang   +41 more
core   +1 more source

KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice

Autoimmunity, 2017
A progressive waning in Foxp3+ regulatory T (Treg) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy.
Mara Kornete, Edward Mason, Roman Istomine, Ciriaco A. Piccirillo   +3 more
doaj   +1 more source

A knowledge integration strategy for the selection of a robust multi-stress biomarkers panel for Bacillus subtilis

Synthetic and Systems Biotechnology, 2023
One challenge in the engineering of biological systems is to be able to recognise the cellular stress states of bacterial hosts, as these stress states can lead to suboptimal growth and lower yields of target products.
Yiming Huang, Nishant Sinha, Anil Wipat, Jaume Bacardit   +3 more
doaj   +1 more source