Results 81 to 90 of about 4,961 (248)

Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry

open access: yesAnnals of Neurology, Volume 97, Issue 6, Page 1205-1214, June 2025.
Objectives Intravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before
Marius Matusevicius   +11 more
wiley   +1 more source

Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis [PDF]

open access: yes, 2020
Background Application of idarucizumab and hemodialysis are options to reverse the action of the oral anticoagulant dabigatran in emergency situations.
Fuhr, Laura Maria   +3 more
core   +1 more source

Impact of Idarucizumab and Andexanet Alfa on DOAC Plasma Concentration and ClotPro® Clotting Time: An Ex Vivo Spiking Study in A Cohort of Trauma Patients

open access: yesJournal of Clinical Medicine, 2021
Specific antagonists have been developed for the reversal of direct oral anticoagulants (DOAC). We investigated the impact of these reversal agents on the plasma concentration and visco-elastic test results of dabigatran and factor Xa inhibitors.
D. Oberladstätter   +6 more
semanticscholar   +1 more source

External validation of the Haemorrhage Estimate Risk in Oral anticoagulation for Mild head trauma nomogram in Hong Kong

open access: yesHong Kong Journal of Emergency Medicine, Volume 32, Issue 2, April 2025.
Abstract Objective Currently, there is no consensus among international guidelines on the management of patients with mild traumatic brain injuries (MTBIs) who are on direct oral anti‐coagulants (DOACs). Overuse of computed tomography (CT) scan of the brain results in unnecessary radiation exposure, longer waits and higher costs.
Ho Man Cheng   +3 more
wiley   +1 more source

Association of Anaesthetists guidelines: the use of blood components and their alternatives

open access: yesAnaesthesia, Volume 80, Issue 4, Page 425-447, April 2025.
Summary Background The administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri‐operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and ...
Akshay Shah   +12 more
wiley   +1 more source

Jefferson Digital Commons quarterly report: October-December 2017 [PDF]

open access: yes, 2018
This quarterly report includes: Assorted assets added to the JDC in the last quarter Grand Rounds Recordings College Within a College (CWIC) Posters Program of Industrial Design Capstones What people are saying about the ...
Copeland, James, LIBT   +2 more
core   +1 more source

Interventional radiology treatments for iatrogenic severe bleeding during percutaneous coronary interventions [PDF]

open access: yes, 2018
Purpose: Interventional cardiology and interventional radiology are separate medical disciplines in which intra-arterial contrast media are used. Interventional cardiology has resigned from many types of treatment techniques that are now used and ...
Brzozowski, Krzysztof   +5 more
core   +1 more source

Intravenous Thrombolysis After Dabigatran Reversal by Idarucizumab: A Systematic Review of the Literature

open access: yesFrontiers in Neurology, 2021
Background and Purpose: Idarucizumab achieves instant reversal of anticoagulation and enables intravenous thrombolysis (IVT) in dabigatran-treated acute ischemic stroke (AIS) patients.
Senta Frol   +4 more
semanticscholar   +1 more source

Chronic kidney disease and arrhythmias: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. [PDF]

open access: yes, 2018
Patients with chronic kidney disease (CKD) are predisposed to heart rhythm disorders, including atrial fibrillation (AF)/atrial flutter, supraventricular tachycardias, ventricular arrhythmias, and sudden cardiac death (SCD).
Amann, Kerstin   +48 more
core   +3 more sources

Spotlight on idarucizumab and its potential for the reversal of anticoagulant effects of dabigatran

open access: yesDrug Design, Development and Therapy, 2016
Pierre Sié Hematology Laboratory, Academic Hospital of Toulouse, Hospital Rangueil, Toulouse, France Abstract: Idarucizumab is the first targeted antidote of dabigatran, a direct oral anticoagulant used for prevention and treatment of venous ...
Sié P
doaj  

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