Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Enhancing design concept diversity: multi-persona prompting strategies for large language models
Design ScienceLarge language models (LLMs) are increasingly used to address real-world design problems, especially during the design ideation phase. Although LLMs hold substantial promise for concept generation, the understanding of how they can effectively assist ...
Wangchuan Bradley Feng +2 more
doaj +1 more source
Network oscillations imply the highest cognitive workload and lowest cognitive control during idea generation in open-ended creation tasks. [PDF]
Sci Rep, 2021 Jia W, von Wegner F, Zhao M, Zeng Y.
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
International Journal of InnovationObjective of the Study: This study aims to investigate the role of artificial intelligence (AI) in enhancing innovation management performance within organizations.
Shah Mehmood Wagan +2 more
doaj +1 more source
Creative, Antagonistic, and Angry? Exploring the Roots of Malevolent Creativity with a Real-World Idea Generation Task. [PDF]
J Creat Behav, 2021 Perchtold-Stefan CM +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Systematisches Innovationsmanagement / Systematic innovation management
GMS Medizin – Bibliothek – Information, 2011 Public institutions (here libraries) are in competition with each other in the same way like companies of the producing industra. Therefore it is crucial for libraries to identify trends early and to respond to customer needs focused and purposefully ...
Georgy, Ursula
doaj
Student Intrinsic Motivation for Online Creative Idea Generation: Mediating Effects of Student Online Learning Engagement and Moderating Effects of Teacher Emotional Support. [PDF]
Front Psychol, 2022 Wang L.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source