Results 71 to 80 of about 10,936,957 (328)
A computational approach for using social networking platforms to support creative idea generation
, 2020 Good design relies upon the generation of good ideas, but producing ideas, especially creative ones, is increasingly challenging. This may be due to limited relevant information, lack of creative skills, design fixation, or as a result of too many ...
Han Ji +3 more
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
World Electric Vehicle JournalSustainability and circular economy are becoming increasingly important for new products due to new EU legislation and serve as orientation for product development.
Fabian Edel +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Journal of IntelligenceCreativity has a dark side—malevolent creativity (MC), which is the application of original ideas to purposely harm others; i.e., creative problem-solving with malicious intent.
Natalie A. Ceballos +2 more
doaj +1 more source
Towards a Taxonomy of Idea Generation Techniques
Foundations of Management, 2019 Business organizations often need to manage creative work. An important way of promoting creative work is to use idea generation techniques (IGTs). Numerous IGTs have been developed, and choosing from such a big pool of candidates can be demanding, which
Wang Kai
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Design Studies, 2019 Reasoning is a fundamental process in design activity, and it provides a way to understand design behaviour. Theories and models of design propose reasoning that follows abductive-deductive patterns. At the micro-level, these patterns are untested.
C. Cramer-Petersen +2 more
semanticscholar +1 more source
Novel Idea-generation Approaches Applied to Wind-turbine Blade Repurposing [PDF]
, 2021 Many engineering problems still require novel solutions, e.g., the repurposing of retired wind-turbine blades. This work investigates novel idea-generation methods that aim to increase the viability of reuse ideas for the currently un-recyclable wind ...
Arabian, Marie-Eugenie Kamie
core +1 more source