Results 121 to 130 of about 10,936,957 (328)

Novel idea generation in social networks is optimized by exposure to a "Goldilocks" level of idea-variability. [PDF]

PNAS Nexus, 2022
Baten RA, Aslin RN, Ghoshal G, Hoque E.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The blind spot of online creative idea generation studies: A perspective of media materiality. [PDF]

Front Psychol, 2022
Liu S, Ji F, Zeng C.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Comparative Study on Online and Offline Teaching for Creative Idea Generation. [PDF]

Front Psychol, 2022
Zhang J, Dai Y, Zhao F.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Reduced brain activity and functional connectivity during creative idea generation in individuals with smartphone addiction. [PDF]

Soc Cogn Affect Neurosci, 2023
Li X, Li Y, Wang X, Hu W.
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Un-Meetings as tools for translational idea generation: A semantic content analysis of an Opioid Crisis Un-Meeting. [PDF]

J Clin Transl Sci, 2022
Yousefi Nooraie R, White RJ, Steele S, Augustine EF, Ossip DJ, Zand MS.   +5 more
europepmc   +1 more source

Enhancing design concept diversity: multi-persona prompting strategies for large language models

Design Science
Large language models (LLMs) are increasingly used to address real-world design problems, especially during the design ideation phase. Although LLMs hold substantial promise for concept generation, the understanding of how they can effectively assist ...
Wangchuan Bradley Feng, Sébastien Hélie, Jitesh H. Panchal   +2 more
doaj   +1 more source