Results 131 to 140 of about 10,936,957 (328)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Utilizing EEG to Explore Design Fixation during Creative Idea Generation. [PDF]

Comput Intell Neurosci, 2021
Cao J, Zhao W, Guo X.
europepmc   +1 more source

Artificial Intelligence in innovation management: Exploring AI's role in enhancing innovation performance

International Journal of Innovation
Objective of the Study: This study aims to investigate the role of artificial intelligence (AI) in enhancing innovation management performance within organizations.
Shah Mehmood Wagan, Muhammad Usman Ashar, Sidra Sidra   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Reimagining Learning Spaces of the Future: An Interprofessional, Virtual Workshop Utilizing Rapid Idea Generation and Lean Startup Methodologies. [PDF]

MedEdPORTAL, 2022
Billings H, Malin T, Allen J, Bergene A, Cornelius K, Craft S, Hartzheim L, Johnson SA, Kallay J, Kreuter J, Raths M, Renner AS, Hall E.   +12 more
europepmc   +1 more source

Systematisches Innovationsmanagement / Systematic innovation management

GMS Medizin – Bibliothek – Information, 2011
Public institutions (here libraries) are in competition with each other in the same way like companies of the producing industra. Therefore it is crucial for libraries to identify trends early and to respond to customer needs focused and purposefully ...
Georgy, Ursula
doaj  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Noninvasive brain stimulation to lateral prefrontal cortex alters the novelty of creative idea generation. [PDF]

Cogn Affect Behav Neurosci, 2021
Kenett YN, Rosen DS, Tamez ER, Thompson-Schill SL.   +3 more
europepmc   +1 more source

Estrategias de socialización del conocimiento formal y su impacto en el comportamiento innovador: un estudio sobre los hoteles del distrito de Santa Marta (Colombia)

Innovar: Revista de Ciencias Administrativas y Sociales
El conocimiento tácito está arraigado en la mente de las personas y puede socializarse (de tácito a tácito) a través de la observación, la imitación y la práctica (Nonaka y Takeuchi, 1995).
Dubys Sofía Regalado Alanche, Gregorio Calderón Hernández   +1 more
doaj   +1 more source

Effect of Backchannel Utterances on Facilitating Idea-Generation in Japanese Think-Aloud Tasks

, 2003
The relation between backchannel utterance and idea-generation has hardly been studied. Based on preliminary investigations, we formulated a hypothesis that a listener's backchannel utterances facilitate a speaker's idea-generation.
Ikue Yamakawa, Machiko Sannomiya, Yusuke Morita, Atsuo Kawaguchi   +3 more
core   +1 more source