Results 141 to 150 of about 10,936,957 (328)

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

open access: yesMolecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan   +8 more
wiley   +1 more source

Perceived human agency and AI-assisted idea generation

open access: yesJournal of Creativity
Large language models (LLMs) are popular tools for creative ideation, but have been shown to homogenize outputs across users. We test if encouraging people to use an AI tool with high (vs.
Sarah H. Wu   +6 more
doaj   +1 more source

Idea Generation Decision Tools: A Comparative Study [PDF]

open access: yes, 2000
A sample of 171 college students was selected, with each participant randomly assigned to one of three treatments. Groups of 3 to 5 students were formed. Each group, using group support system (GSS) software, creativity support system (CSS) software,
Klein, Esther E.
core  

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

open access: yesMolecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis   +20 more
wiley   +1 more source

Improving idea generation and idea management in order to better manage the fuzzy front end of innovation

open access: yes, 2009
An expansive review of the literature on the fuzzy front end of innovation, idea generation, and idea management was conducted and is shown. Based on a depth of understanding, a control model was developed to aid innovation practitioners in effectively ...
Glassman, Brian Scott
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

open access: yesMolecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi   +2 more
wiley   +1 more source

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