Results 101 to 110 of about 4,671,172 (293)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Different Approaches For Protein Engineering In Industrial Biotechnology [PDF]

, 2011
Protein engineering is the novel field which has wide applications from pharmaceutics, industry, commercial, laundry and research. It may apply rational design or non rational design or both.
Muhammad Waheed Akhtar, Israr Khan
core  

Efeito de níveis de lisina digestível verdadeira e proteína bruta na dieta sobre parâmetros morfo-fisiológicos e utilização do nitrogênio em suínos na fase inicial Effect of levels of digestible lysine and crude protein in diets on the organs weight, physiologic parameters, jejune morfometry and nitrogen utilization of the diets for piglets

Ciência e Agrotecnologia, 2007
Foi conduzido um experimento no Departamento de Zootecnia da Universidade Federal de Lavras para verificar a influência de diferentes níveis de proteína bruta (PB) e lisina digestível verdadeira (LISD) na dieta sobre peso de órgãos, parâmetros ...
Márcio Gilberto Zangeronimo, Elias Tadeu Fialho, Luis David Solis Murgas, José Augusto de Freitas Lima, Érika Viviane Heidenheich da Rocha, Renata Ribeiro Alvarenga   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Caracterizando da dieta do estudante da odontología UNNE e sua comparando com uma dieta ideal

, 2021
El presente trabajo de investigación fue realizado para determinar cómo se compone la dieta de los estudiantes que cursan la carrera de Odontología de la UNNE (que alimentos y bebidas consumen a diario), y comparar los resultados obtenidos con los de una
Monzón, Javier, Cuzziol, Fernando Ramiro, Gallego, Claudio, Acuña, Miguel Jorge   +3 more
core  

Digestible methionine + cysteine: lysine ratios for growing meat-type quails

Ciência Rural, 2018
: The objective was to estimate the most appropriate digestible methionine + cysteine:lysine ratios for growing meat-type quails (Coturnix coturnix) from 1 to 21 days of age.
Mariana Resende de Castro, Sandra Regina Freitas Pinheiro, Jéssica Amaral Miranda, Leonardo da Silva Costa, Graziela Maria de Freitas Rocha, Renata Gomes de Oliveira, Paulo Gustavo Macedo de Almeida Martins   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Respostas de frangos de corte a aumentos graduais na relação entre treonina e lisina Broiler responses to graded increases in the threonine to lysine ratio

Ciência Rural, 2007
Um experimento foi conduzido com o objetivo de avaliar o efeito de relações crescentes entre treonina (Thr) e lisina (Lys) digestível em dietas de frangos de corte nas repostas produtivas dos 15 aos 37 dias de idade.
Josemar Berres, Sergio Luiz Vieira, Jorge Luis Bernardon Coneglian, Alexandra Reali Olmos, Dimitri Moreira de Freitas, Tatsi Carolina Kowal Bortolini, Guilherme Xavier da Silva   +6 more
doaj   +1 more source