Results 81 to 90 of about 8,120,287 (316)

Noncovalent synthesis of protein dendrimers

, 2009
The covalent synthesis of complex biomolecular systems such as multivalent protein dendrimers often proceeds with low efficiency, thereby making alternative strategies based on noncovalent chemistry of high interest.
Lempens, E.H.M., Hackeng, T.M., Edith H. M. Lempens, Merkx, M., E. W. Meijer, Baal, van, I., Ingrid van Baal, Meijer, E.W., Dongen, van, J.L.J., Joost L. J. van Dongen, Maarten Merkx, Tilman M. Hackeng   +11 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Desempenho e excreção de nitrogênio de leitões dos 9 aos 25 kg alimentados com dietas com diferentes níveis de lisina digestível e proteína bruta Performance and nitrogen excretion for pigs from 9 to 25 kg submitted to the diets with different levels of digestible lysine and crude protein

Revista Brasileira de Zootecnia, 2007
Dois experimentos foram conduzidos para avaliar níveis de PB e lisina digestível (LISD) na dieta sobre o desempenho e a excreção de nitrogênio (N) de leitões na fase inicial.
Márcio Gilberto Zangeronimo, Elias Tadeu Fialho, Luis David Solis Murgas, Rilke Tadeu Fonseca de Freitas, Paulo Borges Rodrigues   +4 more
doaj   +1 more source

DLIGAND2: an improved knowledge-based energy function for protein–ligand interactions using the distance-scaled, finite, ideal-gas reference state

, 2019
Performance of structure-based molecular docking largely depends on the accuracy of scoring functions. One important type of scoring functions are knowledge-based potentials derived from known three-dimensional structures of proteins and/or protein ...
Zhou, Yaoqi, Yaoqi Zhou, Ke, Yaobin, Yuedong Yang, Yunfei Du, Yutong Lu, Yan, Hui, Lu, Yutong, Huiying Zhao, Chen, Pin, Du, Yunfei, Jiahui Li, Pin Chen, Hui Yan, Li, Jiahui, Zhao, Huiying, Yang, Yuedong, Yaobin Ke   +17 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Níveis de treonina digestível em dietas para codorna japonesa em postura Digestible threonine levels in diets for laying Japanese quail

Revista Brasileira de Zootecnia, 2007
O experimento foi conduzido para estimar o nível de treonina digestível para codornas japonesas em postura, durante 63 dias. Quatrocentas codornas, com idade inicial de 57 dias, foram distribuídas em delineamento inteiramente casualizado com cinco ...
Regina Tie Umigi, Sergio Luiz de Toledo Barreto, Juarez Lopes Donzele, Renata de Souza Reis, Mariele Freitas Sousa, Carla Daniela Suguimoto Leite   +5 more
doaj   +1 more source

Computationally Optimizing the Directed Evolution of Proteins [PDF]

, 2003
Directed evolution has proven a successful strategy for protein engineering. To accelerate the discovery process, we have developed several computational methods to optimize the mutant libraries by targeting specific residues for mutagenesis, and ...
Voigt, Christopher Ashby
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Níveis de lisina digestível em rações para alevinos de tilápia-do-nilo Digestible lysine level in feed for Nile tilapia fingerlings

Revista Brasileira de Zootecnia, 2009
Avaliaram-se níveis de lisina digestível em rações para alevinos de tilápia-do-nilo (Oreochromis niloticus), linhagem tailandesa, com base no conceito de proteína ideal.
Sylvia Sanae Takishita, Eduardo Arruda Teixeira Lanna, Juarez Lopes Donzele, Marcos Antonio Delmondes Bomfim, Moisés Quadros, Maíra Paula de Sousa   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source