Results 61 to 70 of about 453,669 (254)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Revista Brasileira de Zootecnia, 2012 Um experimento foi realizado com o objetivo de estabelecer critérios de avaliação das exigências de treonina digestível para frangos de corte de 22 a 42 dias de idade utilizando-se diferentes modelos de regressão (quadrático, exponencial e de retas ...
Karina Ferreira Duarte +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Dietary protein levels for juvenile matrinxã (Brycon amazonicus) reared in biofloc and clear water systems [PDF]
Revista Brasileira de ZootecniaThis study evaluated the potential for rearing matrinxã (Brycon amazonicus) with different crude protein (CP) levels and using production performance, water quality, and animal welfare as indicators.
Rafaelle Borges Cunha +5 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Revista Brasileira de Zootecnia, 2008 Objetivou-se neste experimento testar diferentes relações lisina digestível:proteína bruta (PB) em dietas para frangos de corte na fase inicial de criação. Utilizou-se um lote misto de 1.800 aves da linhagem Cobb, com um dia de idade.
Kênia Ferreira Rodrigues +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Revista Brasileira de Zootecnia, 2009 Avaliaram-se níveis de lisina digestível em rações para alevinos de tilápia-do-nilo (Oreochromis niloticus), linhagem tailandesa, com base no conceito de proteína ideal.
Sylvia Sanae Takishita +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Digestible valine requirements for broilers from 22 and 42 days old
Acta Scientiarum: Animal Sciences, 2014 Current experiment established different criteria to evaluate the requirements of digestible valine for broilers from 22 and 42 days of age, by different regression models (quadratic, exponential and Linear Response Plateau) and, in the case of ...
Karina Ferreira Duarte +5 more
doaj +1 more source