Results 71 to 80 of about 453,669 (254)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Efeito de níveis de lisina digestível verdadeira e proteína bruta na dieta sobre parâmetros morfo-fisiológicos e utilização do nitrogênio em suínos na fase inicial Effect of levels of digestible lysine and crude protein in diets on the organs weight, physiologic parameters, jejune morfometry and nitrogen utilization of the diets for piglets

Ciência e Agrotecnologia, 2007
Foi conduzido um experimento no Departamento de Zootecnia da Universidade Federal de Lavras para verificar a influência de diferentes níveis de proteína bruta (PB) e lisina digestível verdadeira (LISD) na dieta sobre peso de órgãos, parâmetros ...
Márcio Gilberto Zangeronimo, Elias Tadeu Fialho, Luis David Solis Murgas, José Augusto de Freitas Lima, Érika Viviane Heidenheich da Rocha, Renata Ribeiro Alvarenga   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Digestible methionine + cysteine: lysine ratios for growing meat-type quails

Ciência Rural, 2018
: The objective was to estimate the most appropriate digestible methionine + cysteine:lysine ratios for growing meat-type quails (Coturnix coturnix) from 1 to 21 days of age.
Mariana Resende de Castro, Sandra Regina Freitas Pinheiro, Jéssica Amaral Miranda, Leonardo da Silva Costa, Graziela Maria de Freitas Rocha, Renata Gomes de Oliveira, Paulo Gustavo Macedo de Almeida Martins   +6 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Respostas de frangos de corte a aumentos graduais na relação entre treonina e lisina Broiler responses to graded increases in the threonine to lysine ratio

Ciência Rural, 2007
Um experimento foi conduzido com o objetivo de avaliar o efeito de relações crescentes entre treonina (Thr) e lisina (Lys) digestível em dietas de frangos de corte nas repostas produtivas dos 15 aos 37 dias de idade.
Josemar Berres, Sergio Luiz Vieira, Jorge Luis Bernardon Coneglian, Alexandra Reali Olmos, Dimitri Moreira de Freitas, Tatsi Carolina Kowal Bortolini, Guilherme Xavier da Silva   +6 more
doaj   +1 more source