Results 131 to 140 of about 8,120,287 (316)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Ideal Glasses and Protein Network Dynamics

open access: yes, 2005
Quantitative topological analogies between the flexibilities of optimized inorganic glasses, small biological molecules, and proteins suggest that mean field estimates of internal stress are useful in identifying mechanisms supporting living materials and their enzymatic products.
openaire   +2 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Comparison of Different Ideal Amino Acid Ratios in Male and Female Broiler Chickens of 21 to 42 Days of Age

open access: yesThe Journal of Poultry Science, 2008
An amino acid bioassay was carried out to compare responses of male and female broiler chicks to different ideal amino acid (AA) ratios from 21 to 42d of age.
Reza Taherkhani   +3 more
doaj   +1 more source

Amino acid nutrition and ideal protein for reproductive sows

open access: yes, 2004
The purpose of raising sows is to produce healthy weaning pigs. Sows should be maintained in healthy, strong, and good condition. High-prolific lean type sows have large litter size and high milk production, but low appetite during lactation, and ...
Ji, Fei
core  

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Growth Responses of Broiler Chicks to Different Levels of Threonine and Tryptophan in Chemically-Defined Diets

open access: yesThe Journal of Poultry Science, 2007
In Experiment 1 three semi-purified diets were formulated using isolated soy protein and crystalline amino acids (AA) to contain three profiles of essential amino acids (EAA) based on NRC (1994; Diet 1), Illinois Ideal Chick Protein (IICP; Diet 2) and ...
Robert Blair   +2 more
doaj   +1 more source

Modelling the effects of single point mutations on the structure and function of proteins [PDF]

open access: yes, 2009
Insight into the molecular impact of mutations on the structure and function of proteins is of great importance in biology. It helps understand the evolution of proteins, rationalize the molecular causes of disease and, from a practical perspective, aid ...
Battey, James Nicolas Duncan
core   +1 more source

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