Results 111 to 120 of about 2,577,245 (300)

Identifying Early Signals From Emerging Public Health Events Using Natural Language Processing

Interdisciplinary Perspectives on Infectious Diseases
Timely detection of emerging public health threats is challenging because the surveillance infrastructure is not yet tuned to the emerging threat. We attempt to identify three nonspecific early signals that might be common across emerging events: public ...
Kelly S. Peterson, Christian Dalton, Andrea Kalvesmaki, JoAnn Vuong, Colton Gordon, Senthil Nachimuthu, Mary Jo Pugh, Makoto M. Jones   +7 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Postgrado en Filosofía

Ideas y Valores, 1978
El Consejo Superior Universitario aprobó en su sesión del 9 de mayo de 1978, el Proyecto de Acuerdo que crea el postgrado en filosofía. Publicamos a continuación la exposición de motivos, que acompañó al proyecto y los acuerdos de creación y de ...
. Ideas y Valores
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Solicitude, Emotions, and Narrative in Technology Design Ethics

Études Ricoeuriennes / Ricoeur Studies
The first objective of this paper is to recognize the role of emotion and feeling in Ricœur’s “little ethics” and what they can further add to it, then to explore in more detail how solicitude as a virtue, and affective disposition more broadly, can ...
Paul Hayes, Noel Fitzpatrick
doaj   +1 more source

Contemplative Instagram Girl: mynamesdiana

, 2016
Instagram offers a unique platform for artists to share completed works, ideas, motifs, and in this case, subject matter. Of all the people I could have chosen to draw on Instagram, this radiant individual drew my attention.
Armstrong, Kanchan
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Database--the ideas behind the ideas [PDF]

The Computer Journal, 1975
openaire   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Public Health Decision-Maker Perspective on Joint Clinical Assessments in Central European EU Member States

Journal of Market Access & Health Policy
The HTA R introduces provisions that may benefit member states, in particular the opportunity to share national or regional assessment reports, cooperate outside of clinical domains, or use the methodological guidelines on a local level for technologies ...
Gergő Merész, Dávid Dankó, Márk Péter Molnár   +2 more
doaj   +1 more source