Results 81 to 90 of about 1,025,509 (265)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Identifying Early Signals From Emerging Public Health Events Using Natural Language Processing

Interdisciplinary Perspectives on Infectious Diseases
Timely detection of emerging public health threats is challenging because the surveillance infrastructure is not yet tuned to the emerging threat. We attempt to identify three nonspecific early signals that might be common across emerging events: public ...
Kelly S. Peterson, Christian Dalton, Andrea Kalvesmaki, JoAnn Vuong, Colton Gordon, Senthil Nachimuthu, Mary Jo Pugh, Makoto M. Jones   +7 more
doaj   +1 more source

Topic Timelines for Enabling Close and Distant Reading of Discursive Shifts. A Pilot Case Using Periodicals of European Diabetes Organizations

Journal of Open Humanities Data
In a project about the development of 20th-century patient organizations and their ideas about disease, we are investigating discursive shifts in the organizations’ periodicals—mostly magazines and newsletters—using topic modelling.
Ylva Söderfeldt, Andrew Burchell, Julia Reed, Maria Skeppstedt   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Seciedad colombiana de filosofía

Ideas y Valores, 1978
EI dia 30 de marzo de 1978, se fundó en Bogotá la  Sociedad Colombiana de Filosofía. A continuacion publicamos el Acta de Fundación y los Estatutos de la Sociedad.
. Ideas y Valores
doaj  

Public Health Decision-Maker Perspective on Joint Clinical Assessments in Central European EU Member States

Journal of Market Access & Health Policy
The HTA R introduces provisions that may benefit member states, in particular the opportunity to share national or regional assessment reports, cooperate outside of clinical domains, or use the methodological guidelines on a local level for technologies ...
Gergő Merész, Dávid Dankó, Márk Péter Molnár   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Postgrado en Filosofía

Ideas y Valores, 1978
El Consejo Superior Universitario aprobó en su sesión del 9 de mayo de 1978, el Proyecto de Acuerdo que crea el postgrado en filosofía. Publicamos a continuación la exposición de motivos, que acompañó al proyecto y los acuerdos de creación y de ...
. Ideas y Valores
doaj  

Solicitude, Emotions, and Narrative in Technology Design Ethics

Études Ricoeuriennes / Ricoeur Studies
The first objective of this paper is to recognize the role of emotion and feeling in Ricœur’s “little ethics” and what they can further add to it, then to explore in more detail how solicitude as a virtue, and affective disposition more broadly, can ...
Paul Hayes, Noel Fitzpatrick
doaj   +1 more source