Results 71 to 80 of about 4,882 (214)
Diagnostic Criteria and Management of MELAS and Stroke‐Like Episodes: Consensus‐Based Statements
European Journal of Neurology, Volume 33, Issue 4, April 2026.International Delphi‐based consensus defining MELAS as a clinical syndrome characterized by one or more stroke‐like episodes in the presence of a pathogenic mitochondrial DNA variant, most commonly m.3243A>G. The panel provides practical recommendations for acute and chronic management of stroke‐like episodes and highlights the absence of proven ...
Michelangelo Mancuso +26 more
wiley +1 more source
Phytochemicals in Food and Medicine, Volume 1, Issue 1, March 2026.The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain +5 more
wiley +1 more source
Journal of Current Ophthalmology, 2019 Purpose: To report an accelerated course of visual recovery in a case of Leber's hereditary optic neuropathy (LHON) following treatment with idebenone and hormone replacement therapy (HRT).
Michele Fantini +3 more
doaj +1 more source
Uncoupling Protein-2 Mediates DPP-4 Inhibitor-Induced Restoration of Endothelial Function in Hypertension Through Reducing Oxidative Stress [PDF]
, 2014 published_or_final_versio
Gao, Y +10 more
core +1 more source
Domain Specific Placebo Response in the Modified Friedreich's Ataxia Rating Scale
Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 393-398, February 2026.ABSTRACT The placebo response in clinical trials in ataxias complicates outcome interpretation and potentially obscures genuine treatment effects. We analyzed placebo group data from past trials in Friedreich Ataxia and observed notable responses in appendicular items, in contrast to minimal changes in axial function, as measured by respective ...
Christian Rummey +2 more
wiley +1 more source
Data in Brief, 2016 Here we present some of our data about the interaction of idebenone and idebenol with dipalmitoyl-phosphatidylcholine (DPPC). In particular, we include data of small angle X-ray diffraction (SAXD) and wide angle X-ray diffraction experiments, obtention ...
Victoria Gómez-Murcia +4 more
doaj +1 more source
Loss-of-function genetic diseases and the concept of pharmaceutical targets [PDF]
, 2007 The biomedical world relies heavily on the definition of pharmaceutical targets as an essential step in the drug design process. It is therefore tempting to apply this model to genetic diseases as well.
Laurent Ségalat +10 more
core +5 more sources
Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases
Advanced Science, Volume 13, Issue 11, 23 February 2026.Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh +17 more
wiley +1 more source
Leber’s hereditary optic neuropathy: Update on current diagnosis and treatment
Frontiers in Ophthalmology, 2023 Leber’s hereditary optic neuropathy (LHON) is a fairly prevalent mitochondrial disorder (1:50,000) arising from the dysfunction of the mitochondrial respiratory chain, which eventually leads to apoptosis of retinal ganglion cells.
Ali Esmaeil, Ali Ali, Raed Behbehani
doaj +1 more source
Relationship between aetiology and left ventricular systolic dysfunction in hypertrophic cardiomyopathy [PDF]
, 2015 Background: Hypertrophic cardiomyopathy (HCM) is a common cardiac disease caused by a range of genetic and acquired disorders. The most common cause is genetic variation in sarcomeric proteins genes.
Rosmini, Stefania <1981>
core +1 more source