Results 81 to 90 of about 453,327 (300)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Software-Architecture Recovery from Machine Code [PDF]

, 2013
In this paper, we present a tool, called Lego, which recovers object-oriented software architecture from stripped binaries. Lego takes a stripped binary as input, and uses information obtained from dynamic analysis to (i) group the functions in the ...
Srinivasan, Venkatesh Karthik, Reps, Thomas   +1 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

LSTM Attention-Driven Similarity Learning for Effective Bug Localization

Applied Sciences
Objective: The complexity of software systems, with their multifaceted functionalities and intricate source code structures, poses significant challenges for developers in identifying and resolving bugs.
Geunseok Yang, Jinfeng Ji, Eontae Kim
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Code for: Identifying the Relationship Between Earnings and Prices [PDF]

The files contain code for R, giving possibility to apply the method presented in the article: Starica, C., & Marton, J. (2024). Identifying the relationship between earnings and prices.
Catalin Starica, https://orcid.org/
core   +3 more sources

Identifying Code-Mixing by Influencers in Captions on Social Media: Instagram

Soshum: Jurnal Sosial dan Humaniora
People’s ability to communicate with another person through a combination of verbal and non-verbal means is called language. This study recognizes the use of language in code-mixing in societies of social media. The objective of this study is to identify
Dewa Ayu Andhina Maretha Putri, Ni Nyoman Padmadewi, Luh Putu Artini   +2 more
doaj   +1 more source

A User Feedback Centric Approach for Detecting and Mitigating God Class Code Smell Using Frequent Usage Patterns [PDF]

Journal of Communications Software and Systems, 2019
Code smells are the fragments in the source code that indicates deeper problems in the underlying software design. These code smells can hinder software evolution and maintenance. Out of different code smell types, the God Class (GC) code smell is one of
Randeep Singh, Amit Bindal, Ashok Kumar
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Identifying Codes Kernelization Limitations

CoRR
The Identifying Code (IC) problem seeks a vertex subset whose intersection with every vertex's closed neighborhood is unique, enabling fault detection in multiprocessor systems and practical uses in identity verification, environmental monitoring, and dynamic localization.
Aritra Banik, Praneet Kumar Patra, Adele Anna Rescigno, Abhishek Sahu   +3 more
openaire   +2 more sources