Results 151 to 160 of about 57,488 (195)

Pitfalls in 2HG Detection With TE-Optimized MRS at 3T. [PDF]

J Neuroimaging
Alcicek S, Simicic D, Blair L, Saint-Germain M, Zöllner HJ, Davies-Jenkins CW, Holdhoff M, Laterra J, Bettegowda C, Schreck KC, Lin DD, Barker PB, Kamson DO, Oeltzschner G.   +13 more
europepmc   +1 more source

Mutacije IDH

openaire   +1 more source

Astrocytoma, IDH-mutant

, 2016
openaire   +1 more source

Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM [PDF]

Journal of Personalized Medicine, 2021
Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge. Deep learning showed promising results for IDH identification in mixed low/high grade glioma populations; however, a GBM-specific model is still lacking in the ...
Alberto di Napoli, Martina Lucignani, Antonella Stoppacciaro   +2 more
exaly   +6 more sources

Therapies for IDH-Mutant Gliomas

Current Neurology and Neuroscience Reports, 2023
Abstract Purpose of Review Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct type of primary brain tumors with unique characteristics, behavior, and disease outcomes. This article provides a review of standard of care treatment options and innovative, therapeutic approaches that are currently under ...
Ruham Alshiekh-Nasany, Macarena I de la Fuente, De la Fuente Macarena Ines   +2 more
exaly   +6 more sources

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Characteristics of IDH-mutant gliomas with non-canonical IDH mutation

Journal of Neuro-Oncology, 2020
Approximately 10% of IDH-mutant gliomas harbour non-canonical IDH mutations (non-p.R132H IDH1 and IDH2 mutations).The aim of this study was to analyse the characteristics of non-canonical IDH-mutant gliomas.We retrospectively analysed the characteristics of 166 patients with non-canonical IDH mutant gliomas and compared them to those of 155 consecutive
Charlotte Brönnimann, Catherine Carpentier, H Loiseau   +2 more
exaly   +3 more sources

Biology of IDH mutant cholangiocarcinoma

Hepatology, 2022
Abstract Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are the most frequently mutated metabolic genes across human cancers. These hotspot gain‐of‐function mutations cause the IDH enzyme to aberrantly generate high levels of the oncometabolite, R‐2‐hydroxyglutarate, which competitively inhibits enzymes that regulate epigenetics, DNA repair,
Meng‐Ju Wu, Lei Shi, Joshua Merritt, Andrew X. Zhu, Nabeel Bardeesy   +4 more
openaire   +2 more sources