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Voprosy neirokhirurgii imeni N.N. Burdenko, 2022
Diffuse midline gliomas are relatively rare in adults. Regardless of age, all diffuse midline gliomas are routinely examined in our Center for the presence of the H3F3A K27M gene mutation. However, we identified IDH-mutant brainstem glioma in a 42-year-old man for the first time.
M.V. Ryzhova +5 more
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Diffuse midline gliomas are relatively rare in adults. Regardless of age, all diffuse midline gliomas are routinely examined in our Center for the presence of the H3F3A K27M gene mutation. However, we identified IDH-mutant brainstem glioma in a 42-year-old man for the first time.
M.V. Ryzhova +5 more
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The source of IDH-mutant gliomas
ScienceDeep sequencing of human brain tissue identifies the probable cell of origin of IDH-mutant ...
Christopher W, Mount, Mario L, Suvà
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Abstract The 2021 World Health Organization (WHO) classification defines glioblastoma as a malignant tumor of neuroglial or astroglial origin that lacks mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes. The new definition of glioblastoma also includes IDH-wildtype tumors without histological features of WHO grade 4 if one of ...
Michael Weller +4 more
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Michael Weller +4 more
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No shinkei geka. Neurological surgery, 2023
The 5th edition of the WHO Classification of Central Nervous System Tumours(WHO2021)emphasizes the importance of molecular classification. A significant update was that glioblastoma IDH-mutant from WHO2016 was renamed and classified as astrocytoma IDH-mutant WHO grade 4 in WHO2021.
Ichiyo, Shibahara, Toshihiro, Kumabe
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The 5th edition of the WHO Classification of Central Nervous System Tumours(WHO2021)emphasizes the importance of molecular classification. A significant update was that glioblastoma IDH-mutant from WHO2016 was renamed and classified as astrocytoma IDH-mutant WHO grade 4 in WHO2021.
Ichiyo, Shibahara, Toshihiro, Kumabe
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
Cancer Cell, 2022Samuel K McBrayer +2 more
exaly
IDH Inhibitors for the Treatment of IDH-Mutated Cancer
2019Lenny Dang +2 more
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Abstract Astrocytoma, isocitrate dehydrogenase (IDH)-mutant is diagnosed by the presence of an IDH mutation and no 1p/19q codeletion, usually with loss of ATRX expression. Based on histological criteria three grades are distinguished, the presence of homozygous deletion of the CDKN2A gene in the updated results in the World Health ...
Martin J. van den Bent +3 more
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Martin J. van den Bent +3 more
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Genetic variation between IDH mutant and IDH wild-type glioma
WFNOS 2022 Abstract Book, 2022Shaoqun Li, Mingyao Lai, Linbo Cai
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