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Mutacije IDH

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Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM [PDF]

Journal of Personalized Medicine, 2021
Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge. Deep learning showed promising results for IDH identification in mixed low/high grade glioma populations; however, a GBM-specific model is still lacking in the ...
Alberto DI NAPOLI, Martina Lucignani, Antonella Stoppacciaro   +2 more
exaly   +3 more sources

Therapies for IDH-Mutant Gliomas

Current Neurology and Neuroscience Reports, 2023
Abstract Purpose of Review Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct type of primary brain tumors with unique characteristics, behavior, and disease outcomes. This article provides a review of standard of care treatment options and innovative, therapeutic approaches that are currently under ...
Ruham Alshiekh-Nasany, Macarena De La Fuente   +1 more
exaly   +3 more sources

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Characteristics of IDH-mutant gliomas with non-canonical IDH mutation

Journal of Neuro-Oncology, 2020
Approximately 10% of IDH-mutant gliomas harbour non-canonical IDH mutations (non-p.R132H IDH1 and IDH2 mutations).The aim of this study was to analyse the characteristics of non-canonical IDH-mutant gliomas.We retrospectively analysed the characteristics of 166 patients with non-canonical IDH mutant gliomas and compared them to those of 155 consecutive
Poetsch, L., Bronnimann, C., Loiseau, H., Frénel, J., Siegfried, A., Seizeur, R., Gauchotte, G., Cappellen, D., Carpentier, C., Figarella‑branger, Dominique, Eimer, S., Meyronet, D., Ducray, F.   +12 more
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Biology of IDH mutant cholangiocarcinoma

Hepatology, 2022
Abstract Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are the most frequently mutated metabolic genes across human cancers. These hotspot gain‐of‐function mutations cause the IDH enzyme to aberrantly generate high levels of the oncometabolite, R‐2‐hydroxyglutarate, which competitively inhibits enzymes that regulate epigenetics, DNA repair,
Meng‐Ju Wu, Lei Shi, Joshua Merritt, Andrew X. Zhu, Nabeel Bardeesy   +4 more
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IDH-mutant brainstem glioma

Voprosy neirokhirurgii imeni N.N. Burdenko, 2022
Diffuse midline gliomas are relatively rare in adults. Regardless of age, all diffuse midline gliomas are routinely examined in our Center for the presence of the H3F3A K27M gene mutation. However, we identified IDH-mutant brainstem glioma in a 42-year-old man for the first time.
M.V. Ryzhova, S.A. Galstyan, E.N. Telysheva, D.I. Pitskhelauri, A.V. Kosyrkova, Ya.A. Latyshev   +5 more
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Glioblastoma, IDH-wildtype

Abstract The 2021 World Health Organization (WHO) classification defines glioblastoma as a malignant tumor of neuroglial or astroglial origin that lacks mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes. The new definition of glioblastoma also includes IDH-wildtype tumors without histological features of WHO grade 4 if one of ...
Michael Weller, E. Antonio Chiocca, Sabine Mueller, Jennifer S. Yu, Andreas von Deimling   +4 more
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The source of IDH-mutant gliomas

Science
Deep sequencing of human brain tissue identifies the probable cell of origin of IDH-mutant ...
Christopher W, Mount, Mario L, Suvà
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[Glioblastoma, IDH-Wildtype].

No shinkei geka. Neurological surgery, 2023
The 5th edition of the WHO Classification of Central Nervous System Tumours(WHO2021)emphasizes the importance of molecular classification. A significant update was that glioblastoma IDH-mutant from WHO2016 was renamed and classified as astrocytoma IDH-mutant WHO grade 4 in WHO2021.
Ichiyo, Shibahara, Toshihiro, Kumabe
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