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Voprosy neirokhirurgii imeni N.N. Burdenko, 2022
Diffuse midline gliomas are relatively rare in adults. Regardless of age, all diffuse midline gliomas are routinely examined in our Center for the presence of the H3F3A K27M gene mutation. However, we identified IDH-mutant brainstem glioma in a 42-year-old man for the first time.
M.V. Ryzhova +5 more
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Diffuse midline gliomas are relatively rare in adults. Regardless of age, all diffuse midline gliomas are routinely examined in our Center for the presence of the H3F3A K27M gene mutation. However, we identified IDH-mutant brainstem glioma in a 42-year-old man for the first time.
M.V. Ryzhova +5 more
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No shinkei geka. Neurological surgery, 2023
The 5th edition of the WHO Classification of Central Nervous System Tumours(WHO2021)emphasizes the importance of molecular classification. A significant update was that glioblastoma IDH-mutant from WHO2016 was renamed and classified as astrocytoma IDH-mutant WHO grade 4 in WHO2021.
Ichiyo, Shibahara, Toshihiro, Kumabe
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The 5th edition of the WHO Classification of Central Nervous System Tumours(WHO2021)emphasizes the importance of molecular classification. A significant update was that glioblastoma IDH-mutant from WHO2016 was renamed and classified as astrocytoma IDH-mutant WHO grade 4 in WHO2021.
Ichiyo, Shibahara, Toshihiro, Kumabe
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Characteristics of IDH-mutant gliomas with non-canonical IDH mutation
Journal of Neuro-Oncology, 2020Approximately 10% of IDH-mutant gliomas harbour non-canonical IDH mutations (non-p.R132H IDH1 and IDH2 mutations).The aim of this study was to analyse the characteristics of non-canonical IDH-mutant gliomas.We retrospectively analysed the characteristics of 166 patients with non-canonical IDH mutant gliomas and compared them to those of 155 consecutive
Poetsch, L. +12 more
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Biology of IDH mutant cholangiocarcinoma
Hepatology, 2022Abstract Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are the most frequently mutated metabolic genes across human cancers. These hotspot gain‐of‐function mutations cause the IDH enzyme to aberrantly generate high levels of the oncometabolite, R‐2‐hydroxyglutarate, which competitively inhibits enzymes that regulate epigenetics, DNA repair,
Meng‐Ju Wu +4 more
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Abstract The 2021 World Health Organization (WHO) classification defines glioblastoma as a malignant tumor of neuroglial or astroglial origin that lacks mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes. The new definition of glioblastoma also includes IDH-wildtype tumors without histological features of WHO grade 4 if one of ...
Michael Weller +4 more
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Michael Weller +4 more
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No shinkei geka. Neurological surgery
Abstract Astrocytoma, isocitrate dehydrogenase (IDH)-mutant is diagnosed by the presence of an IDH mutation and no 1p/19q codeletion, usually with loss of ATRX expression. Based on histological criteria three grades are distinguished, the presence of homozygous deletion of the CDKN2A gene in the updated results in the World Health ...
Martin J. van den Bent +3 more
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Abstract Astrocytoma, isocitrate dehydrogenase (IDH)-mutant is diagnosed by the presence of an IDH mutation and no 1p/19q codeletion, usually with loss of ATRX expression. Based on histological criteria three grades are distinguished, the presence of homozygous deletion of the CDKN2A gene in the updated results in the World Health ...
Martin J. van den Bent +3 more
openaire +3 more sources