Results 141 to 150 of about 7,670 (175)

Chemokines in idiopathic inflammatory myopathies

Frontiers in Bioscience, 2008
The idiopathic inflammatory myopathies (IIM) represent a heterogeneous group of acquired muscle diseases. The three best-studied subgroups: dermatomyositis (DM), polymyositis (PM), and sporadic inclusion body myositis (IBM), differ considerably both clinically and pathophysiologically.
Boel, De Paepe, Kim K, Creus, Jan L, De Bleecker   +2 more
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Biologics for idiopathic inflammatory myopathies

Current Opinion in Rheumatology, 2017
Purpose of review As treatment of refractory cases of idiopathic inflammatory myopathies (IIMs) has been challenging, there is growing interest in assessing novel biologics that target various pathways implicated in the pathogenesis of IIM.
Siamak, Moghadam-Kia, Rohit, Aggarwal, Chester V, Oddis   +2 more
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Idiopathic Inflammatory Myopathies

Continuum
This article describes the various idiopathic inflammatory myopathies, including their clinical presentation, pathogenesis, diagnosis, and treatments. While many disorders fall under this umbrella, this article focuses on dermatomyositis, antisynthetase syndrome, immune-mediated necrotizing myopathy, polymyositis, and overlap syndrome.The diagnosis of ...
Mohammad Kian, Salajegheh, Anthony A, Amato   +1 more
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Idiopathic inflammatory myopathies—a review

Clinical Rheumatology, 2015
The idiopathic inflammatory myopathies (IIM) constitute a subset of autoimmune conditions primarily affecting muscle, along with many extra-muscular manifestations. Proximal muscle weakness is the dominant symptom in the IIM. In addition, many patients will have cutaneous manifestations, pulmonary manifestations, and arthritis.
Jonathan, Jones, Robert, Wortmann
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Arthritis in Idiopathic Inflammatory Myopathies

Current Rheumatology Reports, 2019
Arthritis is a well-recognized symptom of idiopathic inflammatory myopathies (IIM). We provide a summary of available data regarding the epidemiology, clinical characteristics, and autoantibody associations of joint involvement in various forms of IIM.Arthritis is reported in 18-55% of patients with IIM.
Martin, Klein, Heřman, Mann, Jiří, Vencovský   +2 more
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Idiopathic inflammatory myopathies – myositis

Best Practice & Research Clinical Rheumatology, 2002
The inflammatory myopathies - myositis - encompass a heterogeneous group of chronic muscle disorders of unknown origin and with varying prognoses. New clinical phenotypes of myositis have been identified since the most widely used classification criteria were proposed in 1975.
Christina, Dorph, Ingrid E, Lundberg
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Idiopathic inflammatory myopathies

Journal of Neuroimmunology, 2011
The idiopathic inflammatory myopathies (IIM) encompass a heterogeneous group of rare disorders that present with acute, subacute, or chronic muscle weakness. Besides overlapping clinical manifestations, polymyositis, dermatomyositis and autoimmune necrotizing myopathy may be associated with cancer or collagen vascular disease, and respond generally ...
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Pathogenesis of idiopathic inflammatory myopathies

Current Rheumatology Reports, 2006
The idiopathic inflammatory myopathies, myositis, are characterized by a chronic course with decreased muscle endurance and by infiltrates of T lymphocytes and macrophages in muscle tissue. Treatment with immunosuppressives rarely leads to recovery of muscle function, despite abolishment of inflammatory cell infiltrates in muscle tissue.
Cecilia, Grundtman, Ingrid E, Lundberg
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Registries in idiopathic inflammatory myopathies

Current Opinion in Rheumatology, 2013
The idiopathic inflammatory myopathies myositis are rare diseases with limited information on risk factors for disease and prognosis. The aim of this review is to give an overview of how registries can be used in myositis research.Population-based registries have been used in a number of incidence and prevalence studies in the review period and have ...
Ingrid E, Lundberg, John, Svensson
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Genetics of the idiopathic inflammatory myopathies

Current Opinion in Rheumatology, 1996
Genetic predisposition to development of the idiopathic inflammatory myopathies is probably multifactorial. Major histocompatibility complex associations with these diseases provide the strongest evidence for a genetic component. In Caucasoids, haplotypes marked by B8/DR3 are associated with each of the clinical subgroups, except mixed connective ...
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