Results 61 to 70 of about 48,457 (271)

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Clinical characteristics of patients with anti-TIF1-γ antibodies

Rheumatology, 2016
Objectives : Inflammatory myopathies are a group of idiopathic, heterogeneous systemic diseases affecting predominantly skeletal muscles, though they can also involve the skin and internal organs.
Anna Masiak, Julia Kulczycka, Zenobia Czuszyńska, Zbigniew Zdrojewski   +3 more
doaj   +1 more source

Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue

Metabolites, 2022
Idiopathic inflammatory myopathy (IIM) is hard to diagnose without a muscle biopsy. We aimed to identify a metabolite panel for IIM detection by metabolomics approach in serum samples and to explore the metabolomic signature in tissue samples from a ...
Jihyun Kang, Jeong Yeon Kim, Youjin Jung, Seon Uk Kim, Eun Young Lee, Joo-Youn Cho   +5 more
doaj   +1 more source

Functioning in adult patients with idiopathic inflammatory myopathy: Exploring the role of environmental factors using focus groups.

PLoS ONE, 2021
ObjectiveHealth-related quality of life is impaired in idiopathic inflammatory myopathies. This study aimed to identify the main areas of the health-related quality of life environment domain that are affected in patients with myositis.MethodsA ...
I Armadans-Tremolosa, G Guilera, M Las Heras, A Castrechini, A Selva-O'Callaghan   +4 more
doaj   +1 more source

Biomarkers in Inflammatory Myopathies – An Expanded Definition [PDF]

, 2019
Biomarkers as parameters of pathophysiological conditions can be of outmost relevance for inflammatory myopathies. They are particularly warranted to inform about diagnostic, prognostic, and therapeutic questions.
Benveniste, Olivier, Goebel, Hans-Hilmar, Stenzel, Werner   +2 more
core   +2 more sources

Dermatomyositis Like Presentation of Anti‐HMGCR Immune Mediated Necrotising Myopathy

JEADV Clinical Practice, EarlyView.
ABSTRACT Extramuscular manifestations of anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) immune‐mediated necrotising myopathy (IMNM) are rare and often overlooked because they are overshadowed by predominant muscular symptoms. The types of cutaneous manifestations can be numerous.
Lionel Leblanc, Lyna Mtimet, Louis Wolff, Evelyne Berlingin, Bruno Couturier   +4 more
wiley   +1 more source

The clinicoserological spectrum of inflammatory myopathy in the context of systemic sclerosis and systemic lupus erythematosus

Indian Journal of Rheumatology, 2020
Autoimmune rheumatic diseases (ARDs) are characterized by a pathological triad composed of autoimmunity/inflammation, microangiopathy, and aberrant tissue remodeling.
John D Pauling, Sarah Skeoch, Julie J Paik   +2 more
doaj   +1 more source

Újabb adatok a myositisspecifikus és -asszociált antitestekről juvenilis és felnőttkori myositisekben [PDF]

, 2016
Absztrakt Az idiopathiás inflammatorikus myopathiák ismeretlen etiológiájú heterogén betegségcsoportot képeznek. Az elmúlt évtizedekben a korai diagnózisnak és az azt követően elkezdett agresszív ...
Dankó, Katalin, Váncsa, Andrea
core   +1 more source

European Consensus on Functional Bloating and Abdominal Distension—An ESNM/UEG Recommendations for Clinical Management

United European Gastroenterology Journal, EarlyView.
ABSTRACT Introduction Abdominal distension is an objective visible sign of increased abdominal girth. Bloating is a feeling of abdominal fullness and discomfort. Bloating may be associated or not with abdominal distension. Bloating and abdominal distension are among the most commonly reported gastrointestinal symptoms and may be associated with both ...
Chloé Melchior, Heinz Hammer, Serhat Bor, Elizabeth Barba, Indira Benjak Horvat, Altay Celebi, Vasile Drug, Dan Dumitrascu, Ismail Hakki Kalkan, Goran Hauser, Christos Lionis, Dan Livovsky, Amir Mari, Agata Mulak, Teodora Surdea‐Blaga, Jan Tack, Tim Vanuytsel, Edoardo Vincenzo Savarino, Natalia Zarate‐Lopez, Johann Hammer, Ram Dickman   +20 more
wiley   +1 more source

Necrotizing Autoimmune Myopathy: A Rare Variant of Idiopathic Inflammatory Myopathies

Journal of Investigative Medicine High Impact Case Reports, 2017
Idiopathic inflammatory myopathies are an unusual group of myopathies with annual incidence of 1 in 100 000 people in the United States. Necrotizing autoimmune myopathy comprises only 16% of this group.
Noman Ahmed Jang Khan MD, Shaza Khalid MD, Saad Ullah MD, Muhammad Umair Malik MD, Samer Makhoul MD   +4 more
doaj   +1 more source