Results 61 to 70 of about 20,247 (257)

Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue

Metabolites, 2022
Idiopathic inflammatory myopathy (IIM) is hard to diagnose without a muscle biopsy. We aimed to identify a metabolite panel for IIM detection by metabolomics approach in serum samples and to explore the metabolomic signature in tissue samples from a ...
Jihyun Kang, Jeong Yeon Kim, Youjin Jung, Seon Uk Kim, Eun Young Lee, Joo-Youn Cho   +5 more
doaj   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Disease course, frequency of relapses and survival of 73 patients with juvenile or adult dermatomyositis [PDF]

, 2005
Objective Our aim is to present the disease course, frequency of relapses and survival of juvenile and adult dermatomyositis (JDM/DM) patients. Methods Analysis was performed using data on 73 patients. The median follow-up for 38 JDM patients was
Balogh, Zsolt, Borgulya, Gábor, Constantin, Tamás, Dankó, K., Fekete, György, Garami, Miklós, Molnár, K., Ponyi, Andrea, Szalai, Zsuzsanna, Tefner, I.   +9 more
core  

Introduction of a novel magnetic resonance imaging-based scoring system for assessing disease activity in children with juvenile dermatomyositis [PDF]

, 2018
Objectives: We aimed to develop and assess the reliability of a novel MRI-based scoring system for reporting the severity of MRI findings in children with suspected JDM.
Adams, Amaka C Offiah, Bohan, Bohan, Brown, Caren Landes, Clarissa Pilkington, Davis, Feldman, Gowdie, Hernandez, Hernandez, Jeannette Kraft, Karl Johnson, Kaufman, Kimball, Love, Lundberg, Maillard, Malattia, Mandela Thyoka, McCann, Oba Adekunle, Owen J Arthurs, Park, Paul Humphries, Pitt, Raj Sinha, Robinson, Stephen Walters, Symmons, Tanimoto, Targoff, Thara Persaud, Van Ness, Walter, Weber   +36 more
core   +2 more sources

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]

, 2009
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D, Burnstock, G, Coutinho-Silva, R, de Araujo-Jorge, TC, Feige, JJ, Higuchi, MD, Waghabi, MC   +6 more
core   +2 more sources

Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes

Arthritis &Rheumatology, Accepted Article.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López, Carlos Rangel‐Peláez, Inmaculada Rodriguez‐Martin, Alfredo Guillen‐Del‐Castillo, Carmen P Simeón‐Aznar, José L Callejas, International SSc Group; PRECISESADs Clinical Consortium, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries‐Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E. Alarcon‐Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta‐Herrera, Martin Kerick   +23 more
wiley   +1 more source

Necrotizing Autoimmune Myopathy: A Rare Variant of Idiopathic Inflammatory Myopathies

Journal of Investigative Medicine High Impact Case Reports, 2017
Idiopathic inflammatory myopathies are an unusual group of myopathies with annual incidence of 1 in 100 000 people in the United States. Necrotizing autoimmune myopathy comprises only 16% of this group.
Noman Ahmed Jang Khan MD, Shaza Khalid MD, Saad Ullah MD, Muhammad Umair Malik MD, Samer Makhoul MD   +4 more
doaj   +1 more source

The clinicoserological spectrum of inflammatory myopathy in the context of systemic sclerosis and systemic lupus erythematosus

Indian Journal of Rheumatology, 2020
Autoimmune rheumatic diseases (ARDs) are characterized by a pathological triad composed of autoimmunity/inflammation, microangiopathy, and aberrant tissue remodeling.
John D Pauling, Sarah Skeoch, Julie J Paik   +2 more
doaj   +1 more source

Újabb adatok a myositisspecifikus és -asszociált antitestekről juvenilis és felnőttkori myositisekben [PDF]

, 2016
Absztrakt Az idiopathiás inflammatorikus myopathiák ismeretlen etiológiájú heterogén betegségcsoportot képeznek. Az elmúlt évtizedekben a korai diagnózisnak és az azt követően elkezdett agresszív ...
Dankó, Katalin, Váncsa, Andrea
core   +1 more source