Results 51 to 60 of about 7,558 (162)

Neuropsychiatric Manifestations of Cognitively Advanced Idiopathic Normal Pressure Hydrocephalus

Dementia and Geriatric Cognitive Disorders Extra, 2018
Background: Neuropsychiatric manifestations of patients with idiopathic normal pressure hydrocephalus (iNPH) have not been studied in a systematic way. Aim: To study the spectrum of neuropsychiatric abnormalities in patients with iNPH.
Robert Mathew, Sauda Pavithran, P. Byju
doaj   +1 more source

Charlson comorbidity index applied to shunted idiopathic normal pressure hydrocephalus

Scientific Reports, 2023
A series of epidemiological studies have shown the limited life expectancy of patients suffering from idiopathic normal pressure hydrocephalus (iNPH). In most cases, comorbid medical conditions are the cause of death, rather than iNPH. Though it has also
Petra M. Klinge, Kevin L. Ma, Owen P. Leary, Rahul A. Sastry, Shanzeh Sayied, Ollin Venegas, Thomas Brinker, Ziya L. Gokaslan   +7 more
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1780-1790, September 2026.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus [PDF]

Continuum, 2016
This article provides neurologists with a pragmatic approach to the diagnosis and treatment of idiopathic normal pressure hydrocephalus (iNPH), including an overview of: (1) key symptoms and examination and radiologic findings; (2) use of appropriate tests to determine the patient's likelihood of shunt responsiveness; (3) appropriate referral to ...
Michael A, Williams, Jan, Malm
openaire   +2 more sources

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus

Frontiers in Aging Neuroscience
Idiopathic normal pressure hydrocephalus in elderly people is considered a form of glymphopathy caused by malfunction of the waste clearance pathway, called the glymphatic system. Tau is a representative waste material similar to amyloid-β.
Namiko Nishida, Nanae Nagata, Keigo Shimoji, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Makio Takahashi, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki, Ryosuke Okumura, Masatsune Ishikawa, Hiroki Toda   +12 more
doaj   +1 more source

Surgical treatment of idiopathic normal pressure hydrocephalus (literature rewiew)

Вестник хирургии имени И.И. Грекова, 2019
Normal pressure hydrocephalus is a pathological condition characterized by ventricular expansion in combination with normal intracranial pressure and manifested by a specific triad of symptoms, including gait disorders, cognitive disorders and urinary ...
G. V. Gavrilov, A. V. Stanishevskiy, B. V. Gaydar, D. V. Svistov   +3 more
doaj   +1 more source

Autopsy Confirmed Normal Pressure Hydrocephalus (NPH) Presenting With Corticobasal Syndrome

Clinical Case Reports, Volume 14, Issue 9, September 2026.
Brain MRI showing DESH, dorsal sulcal crowding, ventriculomegaly, and mild periventricular FLAIR white matter hyperintensities suggestive of trans ependymal edema. ABSTRACT Diagnostic large‐volume CSF drainage should be considered in patients with progressive cognitive/behavioral and motor symptoms localizing to frontal lobes in the presence of MRI ...
Manizhe Eslami Amirabadi, Shubir Dutt, Clair Yballa, Zachary A. Miller, Bruce L. Miller, Renaud La Joie, Salvatore Spina   +6 more
wiley   +1 more source

Diagnosis and management of idiopathic normal-pressure hydrocephalus [PDF]

Neurology Clinical Practice, 2013
The diagnosis and management of idiopathic normal-pressure hydrocephalus (iNPH), a disorder of gait impairment, incontinence, and dementia that affects elderly patients, incorporates an organized approach using familiar principles for neurologists. The starting point is a comprehensive history and neurologic examination, review of neuroimaging, and ...
Michael A, Williams, Norman R, Relkin
openaire   +2 more sources

Progressive Supranuclear Palsy: A Crucial Co-occurrence in Normal Pressure Hydrocephalus or an Etiology of Hydrocephalic Presentation?

Indian Journal of Neurosurgery, 2020
Co-occurrences of neurodegenerative diseases in normal pressure hydrocephalus (NPH) is a remarkable topic of discussion, which has been mentioned in recent studies and it was also emphasized by the International Society for Hydrocephalus and ...
Halil Onder
doaj   +1 more source