Results 111 to 120 of about 47,347 (252)

Plexogenic pulmonary hypertension associated with POEMS syndrome

Respiratory Medicine Case Reports, 2017
Pulmonary hypertension is one of the well-known clinical manifestations of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, occurring in approximately 25–30% of the affected individuals. However, the
Thomas Czeczok, Peter Lin, Eunhee Yi
doaj   +1 more source

Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung disease [PDF]

, 2016
Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung ...
Amoroso, Daria, Barbano, Biagio, DI PAOLO, Marcello, Gigante, Antonietta, Palange, Paolo, Romaniello, Antonella, Rosato, Edoardo, Tallerini, Gaia   +7 more
core   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

Pulmonary Circulation, 2019
In order to intervene appropriately and develop disease-modifying therapeutics for pulmonary arterial hypertension, it is crucial to understand the mechanisms of disease pathogenesis and progression.
Edda Spiekerkoetter, Elena A. Goncharova, Christophe Guignabert, Kurt Stenmark, Grazyna Kwapiszewska, Marlene Rabinovitch, Norbert Voelkel, Harm J. Bogaard, Brian Graham, Soni S. Pullamsetti, Wolfgang M. Kuebler   +10 more
doaj   +1 more source

ЛЕГОЧНАЯ АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ КАК ПРОЯВЛЕНИЕ ПАРАНЕОПЛАСТИЧЕСКОГО СИНДРОМА ПРИ ГИПЕРНЕФРОМЕ

Архивъ внутренней медицины, 2012
We give a case report of idiopathic pulmonary arterial hypertension (PAH) in a male patient with cancer of kidney. The hypothesis of pathogenetic link between these diseases was made.
А. В. Ягода, И. Б. Павлова, Н. Н. Гладких, Ф. С. Семенова, Ю. В. Громова   +4 more
doaj   +1 more source

Caracterización clínica, funcional y hemodinámica de la población con hipertensión pulmonar arterial evaluada en el Instituto Nacional del Tórax [PDF]

, 2006
Pulmonary Arterial Hypertension is a rare, progressive and devastating disease with severe consequences in quality of life and survival. Aim: A clinical, functional and hemodynamic assessment of patients with pulmonary arterial hypertension and ...
Parra R., Claudio, Uriarte G. de C., Polentzi, Wainstein G., Eduardo, Zagolin B., Mónica   +3 more
core   +1 more source

Sustained Idiopathic Outflow Tract Ventricular Tachycardia: Clinical Evidence for RVOT Predominance

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background Idiopathic outflow tract premature ventricular contractions (PVCs) are most commonly localized in the right ventricular outflow tract (RVOT). The clinical significance of sustained outflow tract ventricular tachycardia (OT‐VT) regarding any predominance to one specific anatomic area remains uncertain.
Moneeb Khalaph, Nadica Trajkovska, Maxim Didenko, Mustapha El Hamriti, Guram Imnadze, Denise Guckel, Philipp Lucas, Martin Braun, Thomas Fink, Vanessa Sciacca, Ersan Akkaya, Sebastian E. Beyer, Hassan El‐Shirbiny, Maximilian Mörsdorf, Christian Sohns, Philipp Sommer, Angeliki Darma   +16 more
wiley   +1 more source

Coexistence of pulmonary arterial hypertension and straight back syndrome in a patient with a novel BMPR2 variant affecting cytoplasmic tail domain

European Journal of Medical Research
Background Pathologic variants in the bone morphogenetic protein receptor-2 (BMPR2) gene cause a pulmonary arterial hypertension phenotype in an autosomal-dominant pattern with incomplete penetrance.
Mi Tang, Jun Luo, Qingqing Liu, Jie Song
doaj   +1 more source