Results 91 to 100 of about 29,066 (192)

Axial Connectivity of the Lung Microbiome: A Review of Interorgan Crosstalk

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
The human microbiome mediates immune homeostasis and metabolic signaling across organs. Beyond the gut‐lung axis, crosstalk between the lung and other organ systems is less recognized. This review assesses the axial connectivity of the lung microbiome across the gut, brain, skin, heart, kidney, and liver.
Mathangi Palanivel, Jayanth Kumar Narayana, Sanjay H. Chotirmall   +2 more
wiley   +1 more source

Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management

MedComm, Volume 7, Issue 10, October 2026.
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley   +1 more source

CLINICAL CASE: OPPORTUNITY OF THERAPY OPTIMIZATION DUE TO TRANSITIONING FROM SILDENAFIL TO RIOCIGUAT IN PATIENT WITH IDIOPATHIC PULMONARY HYPERTENSION

Евразийский Кардиологический Журнал, 2016
SUMMERY The patient with diagnosis of idiopathic pulmonary hypertension, functional class III (WHO) was treated by anticoagulants, diuretics. After 6 months of treatment with phosphodiesterase type 5-inhibitor sildenafil, there was observed the negative ...
I. N. Taran, V. M. Paramonov, Z. S. Valieva, M. A. Saidova, S. N. Nakonechnikov, T. V. Martynyuk, I. Ye. Chazova   +6 more
doaj   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Fumarate and Its Esters: Physiology, Pathology, Molecular Mechanisms, Diseases, and Therapy

MedComm, Volume 7, Issue 10, October 2026.
Fumarate is an endogenous immunometabolite that regulates metabolism, redox homeostasis, and inflammation. Although fumaric acid esters (FAEs) share several molecular targets with fumarate, their distinct physicochemical properties confer unique biological activities and therapeutic applications.
Peng Zhu, Mengling You, Yi Zeng, Jinglin Zhang, Si Chen, Rong Rong, Xiaobo Xia   +6 more
wiley   +1 more source

Resolution of Periodic Breathing in a Child with Idiopathic Pulmonary Arterial Hypertension

Case Reports in Pediatrics, 2017
Central sleep apnea (CSA) and periodic breathing are unusual findings described in pediatric patients with congestive heart failure. However, CSA has not been reported in children with pulmonary hypertension.
Saadoun Bin-Hasan, Abdullah Khayat, Tilman Humpl, Janette T. Reyes, Suhail Al-Saleh   +4 more
doaj   +1 more source

Variant Class–Specific Phenotypes and Outcomes in Pediatric TBX4‐Associated Pulmonary Hypertension

Pediatric Pulmonology, Volume 61, Issue 10, October 2026.
ABSTRACT Aim To describe the variant class associations with phenotype, natural history, treatment response, and outcomes in children with TBX4‐associated pulmonary hypertension (TBX4‐PH). Methods Retrospective cohort analysis of children < 18 years referred to the National Paediatric Pulmonary Hypertension Service between 2001 and 2025. Results Twenty‐
Cara Morgan, Alistair Calder, Matina Prapa, Thivya Sekar, Andrew Constantine, Tomas Woodgate, Annabelle Barnes, Eimear McGovern, Paul Aurora, Rossa Brugha, Sadia Quyam, Andrew Bush, Shahin Moledina   +12 more
wiley   +1 more source

A Team‐Based Patient Engagement Approach to Selexipag Initiation and Maintenance in Pulmonary Arterial Hypertension (TEAM PAH): Real‐World Dosing Patterns and Persistence Among Patients With and Without a History of Methamphetamine Use

Pulmonary Circulation, Volume 16, Issue 4, October 2026.
ABSTRACT Selexipag is an oral prostacyclin receptor agonist approved for pulmonary arterial hypertension (PAH). This single‐center, retrospective study described oral selexipag dosing patterns and persistence, overall and stratified by history of methamphetamine (meth) use, at an expert center in California, USA, using a multidisciplinary, nurse ...
Samuel B. Brusca, Amanda Schnell Heringer, Mark Joshua Lacsamana, Anya Thakur, Jonathan Thomas, Christina Benninger, Gurinderpal Doad, Paul Strachan, Sarah Walden, Ambika Satija, Gayatri Marathe, Henrietta Blinder, Marjolaine Gauthier‐Loiselle, Teresa De Marco   +13 more
wiley   +1 more source

Pulmonary Artery Denervation for Persistent Pulmonary Hypertension After Transcatheter Mitral Edge‐to‐Edge Repair: A Pilot Study and First Application in the Post M‐TEER Setting

Pulmonary Circulation, Volume 16, Issue 4, October 2026.
ABSTRACT Pulmonary hypertension (PH) is common in patients undergoing transcatheter mitral edge‐to‐edge repair (M‐TEER) and is an established determinant of adverse outcomes after intervention. Importantly, persistent PH after technically successful M‐TEER remains associated with ongoing symptoms, right ventricular dysfunction and poor prognosis, yet ...
Xiang Chen, Zeying Zhang, Xiaoying Lan, Weibin Chen, Qiuyue Fang, Huaibin Huang, Shaoliang Chen, Yan Wang   +7 more
wiley   +1 more source

Contemporary Economic, Hospitalization, and Mortality Burden Among Pulmonary Arterial Hypertension Patients: A Real‐World US Claims Data Analysis

Pulmonary Circulation, Volume 16, Issue 4, October 2026.
ABSTRACT This study quantified the recent real‐world burden of pulmonary arterial hypertension (PAH) using US real‐world data. Adults (18+) with treated PAH were identified from the MarketScan Commercial/Medicare Databases using a claims‐based algorithm requiring pulmonary hypertension diagnosis, PAH‐specific treatment, and right heart catheterization ...
Ashwin Ravichandran, Amélie Beaudet, David Lopez, Carolyn R. Lew, Helen Varker, Michelle Jerry, Akshay Muralidhar   +6 more
wiley   +1 more source