Results 111 to 120 of about 195,645 (350)

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol [PDF]

, 2019
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life.
Allgar, V., Cohen, J. F., Crooks, M. G., Dyson, J., English, A., Hargreaves, I., Hart, S., Hussain, J., Johnson, M., Richardson, G., Swan, F., Twiddy, M., Wright, C.   +12 more
core   +3 more sources

Applied Artificial Intelligence in Materials Science and Material Design

Advanced Intelligent Systems, EarlyView.
AI‐driven methods are transforming materials science by accelerating material discovery, design, and analysis, leveraging large datasets to enhance predictive modeling and streamline experimental techniques. This review highlights advancements in AI applications across spectroscopy, microscopy, and molecular design, enabling efficient material ...
Emigdio Chávez‐Angel, Martin Børstad Eriksen, Alejandro Castro‐Alvarez, Jose H. Garcia, Marc Botifoll, Oscar Avalos‐Ovando, Jordi Arbiol, Aitor Mugarza   +7 more
wiley   +1 more source

Gender Differences in Survival in Idiopathic Pulmonary Fibrosis and Following Lung Transplant [PDF]

, 2008
Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive form of interstitial lung disease characterized by inflammation and abnormal tissue repair ultimately leading to decreased pulmonary function and death.
Creel, Michael Eric
core  

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Nature Communications, 2020
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF).
Alison E. John, R. Graves, K. Pun, G. Vitulli, E. Forty, P. Mercer, Josie Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, L. Bibby, E. Gower, Valerie S. Morrison, Yim Man, James A Roper, Jeni C. Luckett, L. Borthwick, B. Barksby, R. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, S. Pyne, A. Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, N. S. Gudmann, D. J. Leeming, Rachel C. Chambers, P. Lukey, Richard P. Marshall, Simon J.F. Macdonald, R. Jenkins, Robert J Slack   +36 more
semanticscholar   +1 more source

Heterologous matrix metalloproteinase gene promoter activity allows In Vivo real-time imaging of Bleomycin-induced Lung fibrosis in transiently transgenized mice [PDF]

, 2017
Idiopathic pulmonary fibrosis is a very common interstitial lung disease derived from chronic inflammatory insults, characterized by massive scar tissue deposition that causes the progressive loss of lung function and subsequent death for respiratory ...
Donofrio, Gaetano, Macchi, Francesca, Pompilio, Daniela, Ravanetti, Francesca, Ruscitti, Francesca, Stellari, Fabio Franco, Tebaldi, Giulia, Verna, Andrea Elizabeth, Villetti, Gino   +8 more
core   +1 more source

Metabolic alterations in human pulmonary artery smooth muscle cells treated with PDGF‐BB

Animal Models and Experimental Medicine, EarlyView.
Metabolic abnormalities are considered to play a key regulatory role in vascular remodeling of pulmonary arterial hypertension. We analyzed the metabolome in the culture supernatants of human pulmonary artery smooth muscle cells (PASMC) during the malignant proliferation phenotype transition via a targeted metabolomics method. Significant and extensive
Meng‐Jie Zhang, Jie‐Jian Kou, Hong‐Da Zhang, Xin‐Mei Xie, Yun‐Feng Zhou, Ping Yuan, Xiao‐Bin Pang, Lu‐Ling Zhao, Jing Qiu, Yang‐Yang He   +9 more
wiley   +1 more source

Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? [PDF]

, 2016
Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and multiple internal organs and severe functional and structural microvascular alterations.
Jimenez, Sergio A., Piera-Velazquez, Sonsoles   +1 more
core   +2 more sources

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai, Yongde Jin, Jingmei Chai, Jianing Yang, Jiangang Wang, Mu Chen, Liangchang Li, Chongyang Wang, Guanghai Yan   +8 more
wiley   +1 more source

Familial interstitial pulmonary fibrosis in two different families in India: A case series

Lung India, 2017
Introduction: Idiopathic pulmonary fibrosis (IPF), a chronic progressive interstitial lung disease (ILD), Occasionally, IPF occurs in families. Familial interstitial lung disease has been reported worldwide, limited information is available on the ...
Dabhi Pradipkumar, Arunachal Gautham, Richa Gupta, Prince James, Balamugesh Thangakunam, Devasahayam Jesudas Christopher   +5 more
doaj   +1 more source

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Annals of Neurology, EarlyView.
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr., Bruce A. C. Cree, Stephen L. Hauser   +2 more
wiley   +1 more source